ATP6V0A4 anticorps (C-Term)

N° du produit ABIN965622

Détail du produit anti-ATP6V0A4 anticorps

Antigène: ATP6V0A4 (ATPase, H+ Transporting, Lysosomal V0 Subunit A4 (ATP6V0A4))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATP6V0A4 est non-conjugé

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of Human ATP6V0A4(ATPase, H+ transporting, lysosomal V0 subunit aisoform 4)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur ATP6V0A4

Antigène: ATP6V0A4 (ATPase, H+ Transporting, Lysosomal V0 Subunit A4 (ATP6V0A4))

Autre désignation: ATP6V0A4 (ATP6V0A4 Produits)

Synonymes: anticorps A4, anticorps ATP6N1B, anticorps ATP6N2, anticorps RDRTA2, anticorps RTA1C, anticorps RTADR, anticorps STV1, anticorps VPH1, anticorps VPP2, anticorps Atp6n1b, anticorps a4, anticorps ATPase H+ transporting V0 subunit a4, anticorps ATPase, H+ transporting, lysosomal V0 subunit A4, anticorps ATP6V0A4, anticorps Atp6v0a4

Sujet: ATP6V0A4(ATPase, H+ transporting, lysosomal V0 subunit aisoform 4) is a component of vacuolar ATPase(V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of a hexamer of three A and three B subunits plus the C, D, and E subunits. It contains the ATP catalytic site. The ATP6V0A4 protein is one of three 116 kD subunits family. This family consists of the 116kDa V-type ATPase (vacuolar H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis, Proton Transport