JAK2 anticorps (AA 745-955)

N° du produit ABIN966429

Cité dans 3 publications. Cet anticorps anti-JAK2 Monoclonal Souris (Clone 1C1) (ABIN966429) détecte spécifiquement JAK2 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour JAK2 anticorps (AA 745-955) (ABIN966429)

Antigène: JAK2 (Janus Kinase 2 (JAK2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp JAK2 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 1C1

Détail du produit anti-JAK2 anticorps

Épitope: AA 745-955

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-JAK2 (ABIN966429)

Hermanns, Radtke, Haan, Schmitz-Van de Leur, Tavernier, Heinrich, Behrmann: "Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6651-8, (2000) (PubMed).

Pollack, Kotenko, He, Izotova, Barnoski, Pestka: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." dans: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, (1999) (PubMed).

Mol, de Rijke, Demacker, Stalenhoef: "Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: effects of vitamin E treatment." dans: Atherosclerosis, Vol. 129, Issue 2, pp. 169-76, (1997) (PubMed).

Détails sur JAK2

Antigène: JAK2 (Janus Kinase 2 (JAK2))

Autre désignation: JAK2

Sujet: This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
Synonyms: JTK10, JAK2

Poids moléculaire: 130.6kDa

ID gène: 3717

Pathways: Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response