KCNH1 anticorps (C-Term)

N° du produit ABIN966446

Détail du produit anti-KCNH1 anticorps

Antigène: KCNH1 (Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KCNH1 est non-conjugé

Application: Immunohistochemistry (IHC)

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human KCNH1(Potassium voltage-gated channel subfamily H member 1)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-KCNH1 (ABIN966446)

Schönherr, Gessner, Löber, Heinemann: "Functional distinction of human EAG1 and EAG2 potassium channels." dans: FEBS letters, Vol. 514, Issue 2-3, pp. 204-8, (2002) (PubMed).

Schönherr, Löber, Heinemann: "Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin." dans: The EMBO journal, Vol. 19, Issue 13, pp. 3263-71, (2000) (PubMed).

Pardo, del Camino, Sánchez, Alves, Brüggemann, Beckh, Stühmer: "Oncogenic potential of EAG K(+) channels." dans: The EMBO journal, Vol. 18, Issue 20, pp. 5540-7, (1999) (PubMed).

Occhiodoro, Bernheim, Liu, Bijlenga, Sinnreich, Bader, Fischer-Lougheed: "Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion." dans: FEBS letters, Vol. 434, Issue 1-2, pp. 177-82, (1998) (PubMed).

Détails sur KCNH1

Antigène: KCNH1 (Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1))

Autre désignation: KCNH1 (KCNH1 Produits)

Synonymes: anticorps EAG, anticorps bEAG, anticorps EAG1, anticorps Kv10.1, anticorps h-eag, anticorps M-eag, anticorps Eag1, anticorps kcnh1, anticorps potassium voltage-gated channel subfamily H member 1, anticorps potassium channel, voltage gated eag related subfamily H, member 1, anticorps potassium voltage-gated channel, subfamily H (eag-related), member 1, anticorps potassium voltage-gated channel, subfamily H (eag-related), member 1a, anticorps KCNH1, anticorps LOC490277, anticorps Kcnh1, anticorps kcnh1a

Sujet: KCNH1 (Potassium voltage-gated channel subfamily H member 1) Is a pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. KCNH1 mediates IK(NI) current in myoblasts. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2. KCNH1 interacts with ALG10B. KCNH1 is highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells. Overexpression of EAG may confer a growth advantage to cancer cells and favor tumor cell proliferation.
Synonyms: EAG (Voltage-gated potassium channel subunit Kv10.1), EAG1 (Ether-a-go-go potassium channel 1)