Presenilin 2 anticorps (Presenilin 2 (Alzheimer Disease 4)) (N-Term)

Details for Product anti-PSEN2 Antibody No. ABIN966891, Fournisseur: Connectez-vous pour afficher
Antigène
  • PSEN2
  • ad4
  • ps2
  • ad3l
  • stm2
  • ALG-3
  • Ad4h
  • Alg3
  • PS-2
  • PS2
  • Psnl2
  • STM2
  • pre2
  • zf-PS2
  • AD3L
  • AD4
  • CMD1V
  • PSNL2
  • presenilin 2
  • presenilin 2 S homeolog
  • presenilin 2 (Alzheimer disease 4)
  • PSEN2
  • psen2
  • Psen2
  • psen2.S
Épitope
N-Term
16
6
5
4
4
4
4
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
149
87
80
32
8
6
5
5
5
5
3
3
2
2
1
1
1
1
Hôte
Lapin
85
44
17
4
2
Clonalité
Polyclonal
Conjugué
Cet anticorp Presenilin 2 est non-conjugé
5
5
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
110
77
77
53
36
33
22
13
10
8
3
2
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène A synthetic peptide corresponding to a sequence at the N-terminal of human Presenilin-2, different from the related mouse and rat sequences by two amino acids.< br/>Immunogen was affinity purified.
Isotype IgG
 Réactivité croisée Souris, Rat (Rattus)
Réactivité croisée (Details) No cross reactivity with other proteins.
Attributs du produit Rabbit IgG polyclonal antibody for Presenilin-2 ( PSEN2) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat.
Plasmids, Primers & others Plasmids, Primers & others Presenilin 2 products on genomics-online (e.g. as negative or positive controls)
Autre désignation Presenilin-2(PS-2) (PSEN2 Antibody Extrait)
Sujet Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. [1]Kovacs et al. (1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments (endoplasmic reticulum and Golgi complex). Li et al. (1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes. In melanocytic cells PSEN2 gene expression may be regulated by MITF. [2]
Pathways Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Agent conservateur Sodium azide, Thimerosal (Merthiolate)
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock -20 °C
Stockage commentaire At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Produit citée dans: Hoek, Schlegel, Eichhoff, Widmer, Praetorius, Einarsson, Valgeirsdottir, Bergsteinsdottir, Schepsky, Dummer, Steingrimsson: "Novel MITF targets identified using a two-step DNA microarray strategy." dans: Pigment cell & melanoma research, Vol. 21, Issue 6, pp. 665-76, 2008 (PubMed).

Kaplan, Renbaum, Vreman, Wong, Levy-Lahad, Hammerman, Stevenson: "(TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates." dans: Pediatric research, Vol. 61, Issue 6, pp. 727-31, 2007 (PubMed).

Levy-Lahad, Wijsman, Nemens, Anderson, Goddard, Weber, Bird, Schellenberg: "A familial Alzheimer's disease locus on chromosome 1." dans: Science (New York, N.Y.), Vol. 269, Issue 5226, pp. 970-3, 1995 (PubMed).

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