RPS6KA1 anticorps (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1)

Details for Product anti-RPS6KA1 Antibody No. ABIN966976, Fournisseur: Connectez-vous pour afficher
Antigène
  • HU-1
  • MAPKAPK1A
  • RSK
  • RSK1
  • Rsk1
  • p90rsk
  • rsk
  • RPS6KA
  • hu-1
  • mapkapk1a
  • rsk1
  • wu:fc56h07
  • zgc:152654
  • ribosomal protein S6 kinase A1
  • ribosomal protein S6 kinase polypeptide 1
  • ribosomal protein S6 kinase A1-like
  • ribosomal protein S6 kinase A1 L homeolog
  • ribosomal protein S6 kinase a, polypeptide 1
  • RPS6KA1
  • Rps6ka1
  • RPS6KA1L
  • rps6ka1.L
  • rps6ka1
Reactivité
Humain
389
214
183
51
15
10
8
6
6
4
4
2
2
1
1
1
1
Hôte
386
43
Clonalité
Monoclonal
Conjugué
Cet anticorp RPS6KA1 est non-conjugé
23
22
20
13
13
13
6
6
5
5
5
5
5
5
4
4
4
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
318
194
127
62
62
60
56
46
26
19
6
2
2
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Ni-NTA purified truncated recombinant RSK1 expressed in E. Coli strain BL21 (DE3)
Isotype IgG2a
Purification Crude ascites.
Autre désignation RSK1 (RPS6KA1 Antibody Extrait)
Sujet Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine / threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB. RSK proteins possess two separate kinase domains, the C terminal kinase domain and the N terminal kinase domain, separated by a linker region containing a hydrophobic motif. RSK is activated by many stimuli including growth factors, phorbol esters, cAMP, heat shock, and irradiation.
ID gène 6195
Pathways Signalisation MAPK, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
Indications d'application Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Stock -20 °C
Background publications Sweet, Alcorta, Jones, Erikson, Erikson: "Identification of mitogen-responsive ribosomal protein S6 kinase pp90rsk, a homolog of Xenopus S6 kinase II, in chicken embryo fibroblasts." dans: Molecular and cellular biology, Vol. 10, Issue 5, pp. 2413-7, 1990 (PubMed).

Alcorta, Crews, Sweet, Bankston, Jones, Erikson: "Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase." dans: Molecular and cellular biology, Vol. 9, Issue 9, pp. 3850-9, 1989 (PubMed).

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