tau anticorps

N° du produit ABIN967493

Détail du produit anti-tau anticorps

Antigène: tau (tau Protein)

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp tau est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Marque: BD Pharmingen™

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: TAU-5

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-tau (ABIN967493)

Papasozomenos, Su: "Rapid dephosphorylation of tau in heat-shocked fetal rat cerebral explants: prevention and hyperphosphorylation by inhibitors of protein phosphatases PP1 and PP2A." dans: Journal of neurochemistry, Vol. 65, Issue 1, pp. 396-406, (1995) (PubMed).

Riederer, Binder: "Differential distribution of tau proteins in developing cat cerebellum." dans: Brain research bulletin, Vol. 33, Issue 2, pp. 155-61, (1994) (PubMed).

Watanabe, Takio, Hasegawa, Arai, Titani, Ihara: "Tau 2: a probe for a Ser conformation in the amino terminus of tau." dans: Journal of neurochemistry, Vol. 58, Issue 3, pp. 960-6, (1992) (PubMed).

Ksiezak-Reding, Binder, Yen: "Alzheimer disease proteins (A68) share epitopes with tau but show distinct biochemical properties." dans: Journal of neuroscience research, Vol. 25, Issue 3, pp. 420-30, (1990) (PubMed).

Papasozomenos, Binder: "Phosphorylation determines two distinct species of Tau in the central nervous system." dans: Cell motility and the cytoskeleton, Vol. 8, Issue 3, pp. 210-26, (1988) (PubMed).

Détails sur tau

Antigène: tau (tau Protein)

Autre désignation: Tau (tau Produits)

Synonymes: anticorps DDPAC, anticorps FTDP-17, anticorps MAPTL, anticorps MSTD, anticorps MTBT1, anticorps MTBT2, anticorps PPND, anticorps TAU, anticorps tau, anticorps PHF-tau, anticorps microtubule associated protein tau, anticorps MAPT

Sujet: Tau proteins are microtuble-associated proteins (MAPs) that are thought to function by stabilizing microtubles. They comprise a family of multiple polypeptides that originate from one gene. Alternate splicing of Tau mRNA and differential phosphorylation contribute to the heterogeneity of Tau. Typically, Tau proteins migrate between ~ 45-70 kDa with isoelectric points ranging from 6.5-8.0. Tau expression is widespread in the brain and is found in most cell types within the mammalian central nervous system. Tau has a complex biochemical nature that is partly due to its many isoforms. The number and molecular weights of Tau forms changes during brain development. Additionally, the molecular wieghts and forms of Tau proteins at a given point of development vary between species. Antibodies directed against different epitopes have been used to distinguish between Tau forms. The monoclonal antibody TAU-5 recognizes a phosphorylation-independent epitope on Tau proteins. The reduced molecular weight of Tau proteins may range between 45 kDa to 95 kDa. The TAU-5 antibody reacts with a phosphorylation-independent epitope in the middle of tau. It recognizes both the phosphorylated and non-phosphorylated form of Tau. The antibody has been characterized in rat tissue.

Poids moléculaire: 45-70 kDa