RAB27A anticorps

N° du produit ABIN967619

Détail du produit anti-RAB27A anticorps

Antigène: RAB27A (RAB27A, Member RAS Oncogene Family (RAB27A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RAB27A est non-conjugé

Application: Western Blotting (WB)

Marque: BD Pharmingen™

Attributs du produit: 1. Please refer to us for technical protocols.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human Rab27A

Clone: 20-RAB27

Isotype: IgG1 kappa

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968587

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-RAB27A (ABIN967619)

Yoon, Kovalenko, Bogdanov, Wallach: "MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation." dans: Immunity, Vol. 47, Issue 1, pp. 51-65.e7, (2017) (PubMed).

Hong: "Cytotoxic T lymphocyte exocytosis: bring on the SNAREs!" dans: Trends in cell biology, Vol. 15, Issue 12, pp. 644-50, (2005) (PubMed).

Fukuda: "Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families." dans: Journal of biochemistry, Vol. 137, Issue 1, pp. 9-16, (2005) (PubMed).

Izumi, Gomi, Kasai, Mizutani, Torii: "The roles of Rab27 and its effectors in the regulated secretory pathways." dans: Cell structure and function, Vol. 28, Issue 5, pp. 465-74, (2004) (PubMed).

Détails sur RAB27A

Antigène: RAB27A (RAB27A, Member RAS Oncogene Family (RAB27A))

Autre désignation: RAB27 (RAB27A Produits)

Synonymes: anticorps MGC80943, anticorps RAB27A, anticorps gs2, anticorps ram, anticorps rab27, anticorps MGC89827, anticorps hst18676, anticorps zgc:114135, anticorps GS2, anticorps HsT18676, anticorps RAB27, anticorps RAM, anticorps 2210402C08Rik, anticorps 2410003M20Rik, anticorps 4933437C11Rik, anticorps ash, anticorps RAB27A, member RAS oncogene family L homeolog, anticorps RAB27A, member RAS oncogene family, anticorps RAB27A, member RAS oncogene family S homeolog, anticorps rab27a.L, anticorps RAB27A, anticorps rab27a, anticorps rab27a.S, anticorps Rab27a

Sujet: Members of the Rab family of GTPases are non-transforming, membrane-bound, geranylgeranylated members of the Ras superfamily that are involved in the fusion and trafficking of cellular vesicles. Rab27A is expressed in many human tissues and it regulates the secreation of several types of cellular vesicles, such as melanosomes, insulin granules of pancreatic beta cells, and lytic granules of cytotoxic T lymphocytes. Rab27A is able to regulate such diverse processes by interacting with organelle-specific effector proteins, including melanophilin, granuphilin, and Munc13-4, respectively. Defects in Rab27A function are associated with the human diseases choroideremia and Griscelli syndrome 2 and the ashen mutant mouse. Rab27B is not so widely expressed, yet it is reported to have similar functional capacities as Rab27A.

Poids moléculaire: 25 kDa

Pathways: Peptide Hormone Metabolism