IL-1 beta anticorps

N° du produit ABIN969215

L’anticorps Souris Monoclonal anti-IL-1 beta a été validé pour IHC, ELISA et ICC. Il convient pour détecter IL-1 beta dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour IL-1 beta anticorps (ABIN969215)

Antigène: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-1 beta est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Clone: 3A6

Détail du produit anti-IL-1 beta anticorps

Fonction: IL1B Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human IL1B expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-IL-1 beta (ABIN969215)

Mohideen, Capili, Bilimoria, Yamada, Bonni, Lima: "A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9." dans: Nature structural & molecular biology, Vol. 16, Issue 9, pp. 945-52, (2009) (PubMed).

Kuo, Bentsi-Barnes, Barlow, Bae, Pisarska: "Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene." dans: Cellular signalling, Vol. 21, Issue 12, pp. 1935-44, (2009) (PubMed).

Détails sur IL-1 beta

Antigène: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Autre désignation: IL1B

Sujet: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene.

Poids moléculaire: 31 kDa

ID gène: 3553

UniProt: P01584

Pathways: Signalisation NF-kappaB, Interferon-gamma Pathway, Signalisation TLR, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagy, Cancer Immune Checkpoints, Inflammasome