LCK anticorps

N° du produit ABIN969257

Détail du produit anti-LCK anticorps

Antigène: LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LCK est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogène: Purified recombinant fragment of human Lck expressed in E. coli.

Clone: 8E5F9

Isotype: IgG2a

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-LCK (ABIN969257)

Shi, Cooper, Yu: "A constitutively active Lck kinase promotes cell proliferation and resistance to apoptosis through signal transducer and activator of transcription 5b activation." dans: Molecular cancer research : MCR, Vol. 4, Issue 1, pp. 39-45, (2006) (PubMed).

Stachlewitz, Hart, Bettencourt, Kebede, Schwartz, Ratnofsky, Calderwood, Waegell, Hirst: "A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection." dans: The Journal of pharmacology and experimental therapeutics, Vol. 315, Issue 1, pp. 36-41, (2005) (PubMed).

Hawash, Kesavan, Magee, Geahlen, Harrison: "The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl." dans: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5683-91, (2002) (PubMed).

Détails sur LCK

Antigène: LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))

Autre désignation: Lck (LCK Produits)

Synonymes: anticorps zgc:136695, anticorps LCK, anticorps Hck-3, anticorps Lsk, anticorps Lskt, anticorps p56, anticorps p56Lck, anticorps LSK, anticorps YT16, anticorps p56lck, anticorps pp58lck, anticorps P56LCK, anticorps tkl, anticorps Lck1, anticorps Lcktkr, anticorps LCK proto-oncogene, Src family tyrosine kinase, anticorps lymphocyte protein tyrosine kinase, anticorps lck, anticorps LCK, anticorps Lck

Sujet:

Description: Lck (lymphocyte-specific protein tyrosine kinase), with 509-amino acid protein (about 56 kDa), belongs to the Src non-receptor tyrosine kinases family. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. In addition, inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection.

Aliases: YT16, p56lck, pp58lck

Poids moléculaire: 56 kDa

ID gène: 3932

HGNC: 3932

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling