c-MYC anticorps

N° du produit ABIN969300

Cet anticorps anti-c-MYC est un anticorps Souris Monoclonal détectant c-MYC dans ELISA. Adapté pour Humain. Ce Primary Antibody a été cité dans 3+ publications.

Aperçu rapide pour c-MYC anticorps (ABIN969300)

Antigène: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp c-MYC est non-conjugé

Application: ELISA

Clone: 7E10

Détail du produit anti-c-MYC anticorps

Fonction: MYC Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human MYC expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-c-MYC (ABIN969300)

Fang, Liu, Wu, Liu, Pan, Li: "Upregulation of long noncoding RNA CCAT1-L promotes epithelial-mesenchymal transition in gastric adenocarcinoma." dans: OncoTargets and therapy, Vol. 11, pp. 5647-5655, (2018) (PubMed).

Zhang, Zeng, Jiao, Li, Liu, Zhang, Yang: "AA28-67 domain within MyD88 suppresses c-myc activity and expression to regulate differentiation and function of dendritic cells." dans: Clinical immunology (Orlando, Fla.), Vol. 133, Issue 3, pp. 324-32, (2009) (PubMed).

Lal, Navarro, Maher, Maliszewski, Yan, ODay, Chowdhury, Dykxhoorn, Tsai, Hofmann, Becker, Gorospe, Hide, Lieberman: "miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements." dans: Molecular cell, Vol. 35, Issue 5, pp. 610-25, (2009) (PubMed).

Détails sur c-MYC

Antigène: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Autre désignation: MYC

Sujet: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. (provided by RefSeq).

Poids moléculaire: 49 kDa

UniProt: P01106

Pathways: Signalisation p53, Cycle Cellulaire, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, L'effet Warburg