NAC1 anticorps
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- Antigène Voir toutes NAC1 (NACC1) Anticorps
- NAC1 (NACC1) (Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp NAC1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Purification
- purified
- Immunogène
- Purified recombinant fragment of human NACC1 expressed in E. coli.
- Clone
- 6H2
- Isotype
- IgG1
- Top Product
- Discover our top product NACC1 Anticorps primaire
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- Indications d'application
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- 4°C, -20°C for long term storage
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- Antigène
- NAC1 (NACC1) (Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1))
- Autre désignation
- NACC1 (NACC1 Produits)
- Synonymes
- anticorps BEND8, anticorps BTBD14B, anticorps BTBD30, anticorps NAC-1, anticorps NAC1, anticorps NACC1, anticorps 2010001H03Rik, anticorps 4930511N13Rik, anticorps Btbd14b, anticorps Nac1, anticorps Nac-1, anticorps nucleus accumbens associated 1, anticorps nucleus accumbens associated 1, BEN and BTB (POZ) domain containing, anticorps NACC1, anticorps Nacc1
- Sujet
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Description: NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors . NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system . NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene . The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway . NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4 . Tissue specificity: Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer .
Aliases: NAC1, BEND8, NAC-1, BTBD14B, FLJ37383, NACC1
- Poids moléculaire
- 58 kDa
- ID gène
- 112939
- HGNC
- 112939
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