PDGFRB anticorps (Platelet-Derived Growth Factor Receptor, beta Polypeptide)

Details for Product anti-PDGFRB Antibody No. ABIN969346
Antigène
  • AI528809
  • CD140b
  • PDGFR-1
  • Pdgfr
  • CD140B
  • IBGC4
  • JTK12
  • PDGFR
  • PDGFR1
  • platelet derived growth factor receptor, beta polypeptide
  • platelet derived growth factor receptor beta
  • Pdgfrb
  • PDGFRB
Reactivité
Humain, Souris
510
285
247
9
8
8
8
6
2
2
2
1
1
1
Hôte
Souris
440
95
5
4
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp PDGFRB est non-conjugé
21
15
15
15
15
15
15
15
14
13
11
6
6
6
6
6
4
1
1
1
Application
ELISA, Western Blotting (WB)
305
145
135
83
79
58
57
23
14
12
7
3
2
2
2
1
Options
Immunogène Purified recombinant fragment of human PDGFRbeta expressed in E. Coli.
Clone 1A2
Isotype IgG1
Purification Ascites
Plasmids, Primers & others Plasmids, Primers & others PDGFRB products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation PDGFRbeta (PDGFRB Antibody Extrait)
Sujet Platelet-derived growth factor receptor, beta polypeptide, also known as PDGFRB, PDGFRβ or CD140B. It is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. This family exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor α (PDGFRα) and PDGF receptor β (PDGFRβ). These growth factors are mitogens for cells of mesenchymal origin. PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Poids moléculaire 190 kDa
ID gène 5159
HGNC 5159
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
Indications d'application ELISA: 1:10000, WB: 1:500 - 1:2000
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C,-20 °C
Stockage commentaire 4°C, -20°C for long term storage
Images (Fournisseur)
Western Blotting (WB) image for anti-Platelet-Derived Growth Factor Receptor, beta Polypeptide (PDGFRB) antibody (ABIN969346) Figure 1: Western blot analysis using PDGFRβ mouse mAb against NIH/3T3 cell lysate (1) .
Produit citée dans: Gredmark, Strååt, Homman-Loudiyi, Kannisto, Söderberg-Nauclér: "Human cytomegalovirus downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells." dans: Journal of virology, Vol. 81, Issue 10, pp. 5112-20, 2007 (PubMed).

Wilczynski, Chen, Chen, Howell, Shively, Alberts: "Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers." dans: Human pathology, Vol. 36, Issue 3, pp. 242-9, 2005 (PubMed).

Hansen, Rönnstrand, Rorsman, Hellman, Heldin: "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor." dans: Biochemical and biophysical research communications, Vol. 235, Issue 3, pp. 455-60, 1997 (PubMed).

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