PDGFRB anticorps

N° du produit ABIN969346

Détail du produit anti-PDGFRB anticorps

Antigène: PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PDGFRB est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogène: Purified recombinant fragment of human PDGFRbeta expressed in E. coli.

Clone: 1A2

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-PDGFRB (ABIN969346)

Gredmark, Strååt, Homman-Loudiyi, Kannisto, Söderberg-Nauclér: "Human cytomegalovirus downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells." dans: Journal of virology, Vol. 81, Issue 10, pp. 5112-20, (2007) (PubMed).

Wilczynski, Chen, Chen, Howell, Shively, Alberts: "Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers." dans: Human pathology, Vol. 36, Issue 3, pp. 242-9, (2005) (PubMed).

Hansen, Rönnstrand, Rorsman, Hellman, Heldin: "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor." dans: Biochemical and biophysical research communications, Vol. 235, Issue 3, pp. 455-60, (1997) (PubMed).

Détails sur PDGFRB

Antigène: PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))

Autre désignation: PDGFRbeta (PDGFRB Produits)

Synonymes: anticorps AI528809, anticorps CD140b, anticorps PDGFR-1, anticorps Pdgfr, anticorps CD140B, anticorps IBGC4, anticorps JTK12, anticorps PDGFR, anticorps PDGFR1, anticorps platelet derived growth factor receptor, beta polypeptide, anticorps platelet derived growth factor receptor beta, anticorps Pdgfrb, anticorps PDGFRB

Sujet:

Description: Platelet-derived growth factor receptor, beta polypeptide, also known as PDGFRB, PDGFRβ or CD140B. It is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. This family exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor α (PDGFRα) and PDGF receptor β (PDGFRβ). These growth factors are mitogens for cells of mesenchymal origin. PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Aliases: JTK12, PDGFR, CD140B, PDGFR1, PDGFRB

Poids moléculaire: 190 kDa

ID gène: 5159

HGNC: 5159

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling