CIITA anticorps (AA 1)

N° du produit ABIN97339

Détail du produit anti-CIITA anticorps

Antigène: CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))

Épitope: AA 1

Reactivité: Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CIITA est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: Concentration Definition: by Refractometry

Immunogène: The immunogen used for this study was a bacterially produced recombinant FLAG-CIITA corresponding to through 333 of the human protein.
Immunogentype:Recombinant

Information d'application

Indications d'application: For immunoblotting a 1:500 dilution is recommended. Researchers should determine optimal titers for other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 90 mg/mL

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-CIITA (ABIN97339)

Majumder, Lee, Rahmberg, Kumar, Mi, Scharer, Boss: "A super enhancer controls expression and chromatin architecture within the MHC class II locus." dans: The Journal of experimental medicine, Vol. 217, Issue 2, (2020) (PubMed).

Scharer, Choi, Barwick, Majumder, Lohsen, Boss: "Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment." dans: Nucleic acids research, Vol. 43, Issue 6, pp. 3128-42, (2015) (PubMed).

Koues, Dudley, Mehta, Greer: "The 19S proteasome positively regulates histone methylation at cytokine inducible genes." dans: Biochimica et biophysica acta, Vol. 1789, Issue 11-12, pp. 691-701, (2009) (PubMed).

Détails sur CIITA

Antigène: CIITA (Class II, Major Histocompatibility Complex, Transactivator (CIITA))

Autre désignation: CIITA (CIITA Produits)

Synonymes: anticorps CIITA, anticorps C2ta, anticorps EG669998, anticorps Gm9475, anticorps C2TA, anticorps CIITAIV, anticorps MHC2TA, anticorps NLRA, anticorps Mhc2ta, anticorps class II, major histocompatibility complex, transactivator, anticorps class II major histocompatibility complex transactivator, anticorps MHC class II transactivator, anticorps class II transactivator, anticorps CIITA, anticorps LOC710761, anticorps ciita, anticorps LOC100443575, anticorps Ciita, anticorps LOC100736732

Sujet: Anti-CIITA antibody detects CIITA. The transactivator CIITA regulates basal and interferon-induced expression of Major Histocompatibility Complex class II genes. CIITA restores expression of all MHC class II gene expression in mutant cells and corrects regulatory defects of MHC class II genes. Antibodies to this transactivator are useful in the study of diseases of pathological MHC class II expression. Antigen can be obtained from Raji cell lysates. Typically levels of CIITA expression are too low to detect endogenous levels of protein expression. Transiently transfected cells are usually employed to study this transcription factor.
Synonyms: MHC class II transactivator CIITA MHC2TA

ID gène: 4261

UniProt: P33076

Pathways: Cancer Immune Checkpoints