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anti-Human BCL2L1 Anticorps:
anti-Mouse (Murine) BCL2L1 Anticorps:
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Human Polyclonal BCL2L1 Primary Antibody pour ELISA, IF (p) - ABIN675129
Wang, Ma, Su: NF-?B pathway contributes to cadmium-induced apoptosis of porcine granulosa cells. dans Biological trace element research 2013
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Human Polyclonal BCL2L1 Primary Antibody pour IP, WB - ABIN223050
Cordiali-Fei, Ardigo, Mastroianni, Giuliani, D Agosto, Bordignon, Trento, Vento, Berardesca: Serum cytokines and biohumoral immunological characterization of psoriatic patients in long term etanercept treatment. dans International journal of immunopathology and pharmacology 2008
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Human Polyclonal BCL2L1 Primary Antibody pour IHC - ABIN965653
Cheng, Levine, Boise, Thompson, Hardwick: Bax-independent inhibition of apoptosis by Bcl-XL. dans Nature 1996
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Human Monoclonal BCL2L1 Primary Antibody pour FACS - ABIN135024
Chittenden, Harrington, OConnor, Flemington, Lutz, Evan, Guild: Induction of apoptosis by the Bcl-2 homologue Bak. dans Nature 1995
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Human Polyclonal BCL2L1 Primary Antibody pour IF, IHC - ABIN4368418
Liu, Huang, Zeng, Chen, Huang, Guo, Liu, Xu, Mo, Li: Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway. dans Journal of cancer research and clinical oncology 2011
Human Monoclonal BCL2L1 Primary Antibody pour FACS, IHC - ABIN440456
Punnoose, Leverson, Peale, Boghaert, Belmont, Tan, Young, Mitten, Ingalla, Darbonne, Oleksijew, Tapang, Yue, Oeh, Lee, Maiga, Fairbrother, Amiot, Souers, Sampath: Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models. dans Molecular cancer therapeutics 2016
Human Monoclonal BCL2L1 Primary Antibody pour IF, PLA - ABIN560043
Türkmen, Riehn, Klopocki, Molkentin, Reinhardt, Burmeister: A BACH2-BCL2L1 fusion gene resulting from a t(6;20)(q15;q11.2) chromosomal translocation in the lymphoma cell line BLUE-1. dans Genes, chromosomes & cancer 2011
Human Monoclonal BCL2L1 Primary Antibody pour FACS - ABIN135023
Rajah, Bhala, Nunn, Peehl, Cohen: 7S nerve growth factor is an insulin-like growth factor-binding protein protease. dans Endocrinology 1996
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Human Monoclonal BCL2L1 Primary Antibody pour FACS - ABIN135021
Kiefer, Brauer, Powers, Wu, Umansky, Tomei, Barr: Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. dans Nature 1995
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BCL-XL promotes stemness and contributes to the aggressiveness of both melanoma and glioblastoma.
inhibition of the BCL2 family member BCLxL resulted in nanomolar potency against human synovial sarcoma cell lines and 50% tumor reduction in a genetically engineered mouse model
In this study, we investigated whether APG (Montrer SMAD1 Anticorps)-1252-12A inhibits the growth of five leukemia cell lines in a concentration- or time-dependent manner by MTS (Montrer TIMM8A Anticorps) assay.APG-1252-12A is a Bcl-2 (Montrer BCL2 Anticorps) homology (BH)-3 mimetic that specifically binds to Bcl-2 (Montrer BCL2 Anticorps) and Bcl-xl, which has shown efficacy in some Bcl-2 (Montrer BCL2 Anticorps) dependent hematological cancers
inhibition of Bcl-xL induces significantly more apoptosis in IDH1 (Montrer IDH1 Anticorps)-mutated cells than in wild-type IDH1 (Montrer IDH1 Anticorps) cells.
CCAT1 is upregulated in docetaxel-resistant lung adenocarcinoma cells; its oncogenic function depends on sponging of let-7c, which releases Bcl-xl, promoting the acquisition of chemoresistance and epithelial-to-mesenchymal transition phenotypes
In the epithelial ovarian cancer stem cells, 40% knock-down of Bclxl expression was sufficient to induce the full activation of caspases. Bclxl expression levels in EOC cells is dynamic and can be regulated by microenvironments that are enriched with the pro-inflammatory cytokine IL-6 (Montrer IL6 Anticorps) such as the cancer stem cell and adipocyte niches.
Study reports the interaction of BCL-XL with RASSF6 (Montrer RASSF6 Anticorps). BCL-XL inhibits the interaction between RASSF6 (Montrer RASSF6 Anticorps) and MDM2 (Montrer MDM2 Anticorps) and suppresses p53 (Montrer TP53 Anticorps) expression. Consequently, BCL-XL antagonizes RASSF6 (Montrer RASSF6 Anticorps)-mediated apoptosis. Thus, the inhibition of RASSF6 (Montrer RASSF6 Anticorps)-mediated apoptosis also underlies the prosurvival role of BCL-XL.
anti-apoptotic molecules BclxL and Bcl-2 (Montrer BCL2 Anticorps) and the pro-apoptotic factors BAD and BID (Montrer BID Anticorps) cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L (Montrer FASL Anticorps).
These results show that mRNA expression in centenarians is unique and reveals that Bcl-xL plays an important role in exceptional aging.
that Ubiquitin-specific peptidase 18 (Montrer USP18 Anticorps) directly bind to BCL2L1 and positively regulated its expression in hepatocellular carcinoma cells
targeting BCLxL in human and mouse synovial sarcoma with the small molecule BH3 domain inhibitor, BXI-72, achieved significant cytoreduction and increased apoptotic signaling.
GATA-3 (Montrer GATA3 Anticorps) participates in the healing of bone fractures via regulating bcl-xL gene expression, owing to its association with Runx2 (Montrer RUNX2 Anticorps).
this study demonstrates that necrosis of Mycobacterium tuberculosis-infected macrophages is dependent on the action of Bcl-xl
Mitochondrial Bcl-xL is involved in maintaining mitochondrial respiratory capacity. Its deficiency causes oxidative stress, which is associated with an increased glycolytic capacity and balanced by an increased activity of the pentose phosphate pathway.
Proapoptotic proteins BIM (Montrer BCL2L11 Anticorps) and PUMA (Montrer BBC3 Anticorps) are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL.
BMP4 (Montrer BMP4 Anticorps) promotes survival of neural stem/progenitor cells by enhancing the anti-apoptotic function of Bcl-xL via BMP4 (Montrer BMP4 Anticorps)-Smad1 (Montrer SMAD1 Anticorps)/5/8-Id1 (Montrer ID1 Anticorps) signaling in the presence of FGF-2 (Montrer FGF2 Anticorps).
We propose that the GC-induced mitochondrial accumulation of Bax (Montrer BAX Anticorps) and the interaction between the GR and Bim (Montrer BCL2L11 Anticorps), Bcl-xL and Bak (Montrer BAK1 Anticorps) could play a role in the regulation of thymocyte apoptosis.
Bcl-xL is required for survival of post mitotic neurons throughout the developing spinal cord.
amplification and characterization of partial regions of exons 2 and 3 of the bovine BCL2L1 gene
Data show that Bcl-x(L) expression is increased in the pulmonary artery undergoing chronic pulmonary vascular remodeling.
interleukin-6 (Montrer IL6 Anticorps), endothelin ET-1 (Montrer EDN1 Anticorps), and apoptotic Bak (Montrer BAK1 Anticorps) and Bcl-XL genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
Bcl-xL was significantly decreased in haploid parthenotes compared with the diploid parthenotes. These results suggest that the haploid state affects apoptosis-related gene expression which results in increased apoptosis
CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (Montrer BCL2 Anticorps) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.
Bcl-Xl deamidation and methylation has a role in protein isoaspartate methyltransferase prevention of apoptosis induced by oxidative stress in endothelial cells
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (Montrer TNF Anticorps), IL-6 (Montrer IL6 Anticorps), IL-12p40, IL-1beta (Montrer IL1B Anticorps), and resulted in increased expression of the apoptosis initiator caspase-8 (Montrer CASP8 Anticorps) and bcl2L1.
This study leads to conclude that BCLXL peak expression at the zygotic genome activation phase may be a requirement for embryo development
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of BCL2L1 transcripts and protein depending on luteal stage.
repression of radiation-induced apoptosis by overexpression of Bcl-xL during embryonic development depends upon the timing of its expression and post-translational events that enable the protein to become effective
The bcl2l gene operates in the inhibition of cell death under direct regulation of a thyroid specific set of transcription factors
Zebrafish anti-apoptotic gene Bcl-xL can prevent aquatic birnavirus-induced cell death in fish cells without affecting expression of viral proteins.
transgenic overexpression of zfBLP1 or myeloid cell leukemia sequence 1a in zebrafish larvae interrupts regulation of the homeostatic balance between cell proliferation and programmed cell death during hepatogenesis and leads to liver hyperplasia
Bcl-xL can block post-apoptotic necrosis processes thereby rescuing betanodavirus-infected cells
Delta113p53 functions to antagonize p53 (Montrer TP53 Anticorps)-induced apoptosis via activating bcl2L
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
apoptosis regulator Bcl-X
, bcl-2-like protein 1
, protein phosphatase 1, regulatory subunit 52
, B-cell leukemia/lymphoma x
, anti-apoptosis regulatory protein
, B cell lymphoma 2 like
, B cell lymphoma like X
, BCL2-like protein 1
, anti-apoptotic Bcl-xL
, BCLX protein
, BCL2-like 1
, apoptosis regulator R11
, Bcl-xL-like protein 1