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anti-Human Desmoglein 2 Anticorps:
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Human Monoclonal Desmoglein 2 Primary Antibody pour IHC (fro), IP - ABIN2473331
: [The 5th consensus conference on intensive care and emergency medicine. Diagnosis of nosocomial pneumopathies in intensive care. 13 October 1989, Bicêtre]. dans La Revue du praticien 1990
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Human Monoclonal Desmoglein 2 Primary Antibody pour IHC (fro), WB - ABIN2191994
Wahl, Sacco, McGranahan-Sadler, Sauppé, Wheelock, Johnson: Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains. dans Journal of cell science 1996
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Human Monoclonal Desmoglein 2 Primary Antibody pour ICC, IF - ABIN1169682
Keim, Johnson, Wheelock, Wahl: Generation and characterization of monoclonal antibodies against the proregion of human desmoglein-2. dans Hybridoma (2005) 2008
Human Monoclonal Desmoglein 2 Primary Antibody pour EIA, IHC (fro) - ABIN112136
Franke, Nuber, Schmidt, Schäfer: Desmosomes--dual junctional principles of intra- and supracellular order in epithelial differentiation and tissue formation. dans Verhandlungen der Deutschen Gesellschaft für Pathologie 1995
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Human Polyclonal Desmoglein 2 Primary Antibody pour ICC, IF - ABIN4305012
Asplund, Gry Björklund, Sundquist, Strömberg, Edlund, Ostman, Nilsson, Pontén, Lundeberg: Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma. dans The British journal of dermatology 2008
Cow (Bovine) Polyclonal Desmoglein 2 Primary Antibody pour IHC, WB - ABIN2782147
Cirillo, Lanza, De Rosa, Cammarota, La Gatta, Gombos, Lanza: The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery. dans Journal of cellular biochemistry 2008
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DSG2 as a key regulator of vasculogenic mimicry (VM) activity in human melanoma and suggest this molecule might be therapeutically targeted to reduce tumor blood supply and metastatic spread.
Data suggest that Dsg2 stimulates cell growth and migration by positively regulating EGFR (Montrer EGFR Anticorps) level and signaling through a c-Src (Montrer SRC Anticorps) and Cav1 (Montrer CAV1 Anticorps)-dependent mechanism using lipid rafts as signal modulatory platforms.
identified DSG2 expression in distinct progenitor cell subpopulations and show that, independent from its classical functi (Montrer HBA1 Anticorps)on as a component of desmosomes, this cadherin also plays a critical role in the vasculature
Data show that fetal pMSCs (mesenchymal stromal cells) expressing the highest levels of desmoglein 2, desmocollin 3 (Montrer DSC2 Anticorps) and plakophilin 2 (Montrer PKP2 Anticorps), followed by maternal pMSCs, while bmMSCs expressed the lowest levels.
Expression of the desmosomal protein Desmoglein-2 was reduced in pediatric dilated cardiomyopathy pediatric patients.
This study defines a mechanism by which Dsg2 expression in cancer cells can modulate the tumor microenvironment, a step critical for tumor progression.
Silencing of Dsg2 but not Dsc2 (Montrer DSC2 Anticorps) resulted in loss of cell cohesion and enhanced migration, and invasion of pancreatic adenocarcinoma cells.
The homozygous desmoglein 2 variant c.1003A;G co-segregated with Arrhythmogenic right ventricular cardiomyopathy, indicating autosomal recessive inheritance and complete penetrance.
these data suggest that palmitoylation of Dsg2 regulates protein transport to the plasma membrane. Modulation of the palmitoylation status of desmosomal cadherins can affect desmosome dynamics.
Both Dsg2 mRNA and protein were highly expressed in non-small cell lung cancer (NSCLC) tissues and associated with NSCLC size, but not with overall survival of patients.
generated a Dsg2 loss-of-function strain (Dsg2 (lo/lo)) and observed that, in response to reduced levels of Dsg2: (i) CD31 (Montrer PECAM1 Anticorps)(+) endothelial cells in the pancreas are hypertrophic and exhibit altered morphology, (ii) bone marrow-derived endothelial colony formation is impaired, (iii) ex vivo vascular sprouting from aortic rings is reduced, and (iv) vessel formation in vitro and in vivo is attenuated
Data suggest that loss of desmoglein 2 (Dsg2) compromises adhesion, and that this is a major pathogenic mechanism in DSG2-related and probably other desmosome-related arrhythmogenic cardiomyopathy (AC).
Dsg2 modulates Gli1 (Montrer GLI1 Anticorps) expression. Dsg2-mediated hyperproliferation, MEK (Montrer MDK Anticorps)/Erk1/2 activation, and accelerated squamous tumor development are enhanced on the Ptc1 (Montrer PTCH1 Anticorps)+/lacZ (Montrer GLB1 Anticorps) background.
a novel pathway of CSTA (Montrer CSTA Anticorps) regulation involving Dsg2
Data demonstrate that desmoglein-2 plays a critical role in cardiomyocyte cohesion and function.
Data demonstrate that partner desmosomal cadherins Dsg2 and Dsc2 (Montrer DSC2 Anticorps) play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR (Montrer EGFR Anticorps) signaling.
Dsg2 compensates for Dsg3 (Montrer DSG3 Anticorps) depletion with regard to cell cohesion, but does not regulate p38 MAPK (Montrer MAPK14 Anticorps) signaling.
In vivo interaction between Dsg2 and Na(V)1.5 provides a molecular pathway for the observed electrical disturbances during the early arrhythmogenic right ventricular cardiomyopathy.
Mutant desmoglein 2 cannot support the increased requirements placed on intercalated disc adhesion during postnatal heart development. This induces cardiomyocyte death, aseptic inflammation and fibrotic replacement.
ventricular arrhythmias that has been linked to mutations in desmosomal proteins including desmoglein 2
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.
, Dsg alpha
, desmocollin a
, cadherin family member 5