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Human Chemokine (C-C Motif) Ligand 5 (CCL5) interaction partners

1. CCL5 autocrine loop may promote ESCC progression.

2. To sum up, this study demonstrates that chronic alcohol consumption may promote metastasis of colorectal cancer through CCL5-induced autophagy.

3. Result suggests that in early non-alcoholic steatohepatitis (NASH), hepatic stellate cells secrete Ccl5 which contributes to a broad array of mechanisms by which hepatic steatosis and inflammation are achieved.

4. this study shows the association of CCL5 expression with clinicopathological features and the recruitment of tumor-infiltrating lymphocytes and subsets of immune cells in triple negative breast cancer, and its influence in patients' outcome

5. SNP in CCL5 gene (rs2107538) may affect serum chemokine levels.

6. CCL5 polymorphism rs2280788C is associated with Japanese encephalitis virus (JEV) infection and CCL5 protein levels correlate with fatal JEV infection outcome in Indian population.

7. CCL5 may contribute to promoting tumor growth, and CCL5 is a promising target that may help in understanding the pathogenesis of colorectal cancer

8. an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5

9. CCL5 rs2280789 G alleles were associated with higher VEGF-A levels.

10. This study provided evidence that miR-146a targets CCL5 3' untranslated regions, downregulates its release from macrophages, and affects monocyte migration consequently. These findings drew a novel layer of posttranscriptional control of the chemokine CCL5 by miR-146a during HIV infection, which might contribute to HIV pathogenesis.

11. Long noncoding RNA SNHG16 regulated LPS-induced inflammation injury in WI-38 cells through competitively binding miR-146a-5p with CCL5 further mediating JNK and NF-kappaB pathways, which sheds novel light on diagnostics and therapeutics in pneumonia.

12. The CCL5 rs2107538 polymorphism was identified to be associated with a significantly lower risk of benign prostatic hyperplasia (BPH). This polymorphism was also associated with the development of larger prostate volumes in Chinese patients with BPH.

13. This study explored the interaction of CCL5 with GPR75, an orphan receptor of the Gqalpha family of GPCRs, which appears to be expressed more abundantly in neuron-like cells than astrocytes.

14. data show that a genetic variant of CCL5 confers protection against Chagas heart disease

15. CCL5 deficiency could reverse obliterative changes in pulmonary arteries via caveolin-1-dependent amplification of BMPR2 signaling.

16. loss of CCL5 could enhance CXCL1 expression in hepatocytes and activate CXCL1-CXCR2 axis in neutrophils to augment their hepatic infiltration

17. these findings show that IL-6 and CCL5 signaling, which promote crosstalk between triple-negative breast cancer (TNBC) and lymphatic vessels, are key enhancers of TNBC tumor growth and metastasis. Furthermore, these results demonstrate that a drug combination inhibiting these pathways may be a promising therapy for TNBC patients

18. CCL5/CCR5 axis may be involved in the perineural invasion of salivary adenoid cystic carcinoma cells

19. In burn wounds, RANTES/CCL5 levels were on average 14.86pg/ml in young vs 4.26pg/ml in aged (p=0.026).

20. Combination of IP-10 and RANTES could be potentially used as diagnostic and monitoring biomarker in pulmonary tuberculosis management.

Mouse (Murine) Chemokine (C-C Motif) Ligand 5 (CCL5) interaction partners

1. Our study provides the first evidence of an exercise-reducible myokine, CCL5, in the mouse skeletal muscle.

2. our results demonstrate a sequence of early events elicited by CCL5 chemoattracting macrophage that result in inflammatory aggravation of hepatic IRI.

3. loss of CCL5 could enhance CXCL1 expression in hepatocytes and activate CXCL1-CXCR2 axis in neutrophils to augment their hepatic infiltration

4. the results show that Broadleaf Mahonia is a novel effective antiinflammatory herb in vitro and ex vivo, and that CCL5 may be closely associated with Granulomatous lobular mastitispathogenesis

5. miR-155 enhances venous neointima formation through the autocrine and paracrine effects of smooth muscle-like cell-derived RANTES in a nuclear factor kappaB-dependent manner in arteriovenous shunts.

6. Macrophage subtypes enhanced the osteogenesis in transwell setting and the transition from M1 to M2 was associated with an increase in bone anabolic factors CCL2/MCP-1, CCL5/RANTES and IGF-1 in vitro.

7. Taken together, our data suggest that CCR5 regulates insulin signaling in hypothalamus which contributes to systemic insulin sensitivity and glucose metabolism.

8. identifies the essential role of the chemoattractive cytokine CCL5 for liver disease progression and especially hepatocellular carcinoma development

9. Breast cancer cell CCL5 mediates bone marrow independent angiogenesis via paracrine signaling.

10. Studied the effects of CCL5-CCR5 interactions in breast cancer metabolism, and findings suggest that CCL5-CCR5 interactions in the tumor microenvironment modulate metabolic events during tumor onset to promote tumorigenesis.

11. RANTES levels were associated with TMS measures of cortical synaptic excitability, but not with long-term potentiation (LTP)-like plasticity.

12. study found that the inflammatory chemokine CCL5 is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN-expressed D6.

13. A robust up-regulation of RANTES within the brain was seen in a mouse model of tick-borne encephalitis.

14. CCL5 paradoxically limits macrophage accumulation in the injured kidney during renin angiotensin system (RAS) activation by constraining the proinflammatory actions of CCL2.

15. This study showed that RANTES is important in the regulation of vascular dysfunction through modulation of perivascular inflammation.

16. IL-6 Mediates Macrophage Infiltration after Irradiation via Up-regulation of CCL2/CCL5 in Non-small Cell Lung Cancer

17. Blocking antibodies against RANTES and eotaxin reduced the infiltration of CD4(+) and CD8(+) T cells into the nigra, attenuated nigral expression of proinflammatory molecules, and suppressed nigral activation of glial cells. These findings paralleled dopaminergic neuronal protection, normalized striatal neurotransmitters, and improved motor functions in MPTP-intoxicated mice.

18. CCL5 deficiency resulted in reduced neointima formation after carotid artery injury and thrombosis.

19. RANTES produced by renal tubular cells act as a key chemokine in acute kidney injury and HIF-1alpha regulated LncRNA-PRINS might be involved in RANTES production.

20. Mycobacterium chelonae activates the gene expressions of chemokine (C-C motif) ligand 2 (CCL2) and CCL5 in murine bone marrow-derived macrophages and in vivo mouse model.

Pig (Porcine) Chemokine (C-C Motif) Ligand 5 (CCL5) interaction partners

1. These results represent an important molecular mechanism whereby H. parasuis induced RANTES in the inflammatory response.

2. Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription.

3. we cloned the nucleotide sequence of the 5'-flanking region of the porcine RANTES (poRANTES) gene and characterized the regulatory elements that activate transcription

4. The Toll-like receptor signaling pathway is involved in porcine reproductive and respiratory syndrome virus-induced RANTES activation.

5. These results suggest that porcine RANTES can play an important role in xenotransplant rejection, through participating in the interaction between porcine endothelial cells and human monocytes.

Cow (Bovine) Chemokine (C-C Motif) Ligand 5 (CCL5) interaction partners

1. CCL5 but not CCL2 mainly attract bovine classical monocytes and promote their differentiation into LPS-hypo-responsive macrophages.

2. decrease in sensitivity of HIV variants to RANTES neutralization during the course of progressive infection, but not during follow-up of long term survivors; data suggest a role for RANTES neutralization sensitivity of HIV-1 in AIDS pathogenesis

Guinea Pig Chemokine (C-C Motif) Ligand 5 (CCL5) interaction partners

1. In the pathogenesis of allergic rhinitis, substance P induces expression of RANTES in nasal mucosa.

Rhesus Monkey Chemokine (C-C Motif) Ligand 5 (CCL5) interaction partners

1. CCL3, CCL4 and CCL5 gene expression was evaluated in response to simian-human immunodeficiency virus (SHIV) infection in a rhesus macaque model.