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CCL5 autocrine loop may promote ESCC progression.
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To sum up, this study demonstrates that chronic alcohol consumption may promote metastasis of colorectal cancer through CCL5-induced autophagy.
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Result suggests that in early non-alcoholic steatohepatitis (NASH), hepatic stellate cells secrete Ccl5 which contributes to a broad array of mechanisms by which hepatic steatosis and inflammation are achieved.
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this study shows the association of CCL5 expression with clinicopathological features and the recruitment of tumor-infiltrating lymphocytes and subsets of immune cells in triple negative breast cancer, and its influence in patients' outcome
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SNP in CCL5 gene (rs2107538) may affect serum chemokine levels.
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CCL5 polymorphism rs2280788C is associated with Japanese encephalitis virus (JEV) infection and CCL5 protein levels correlate with fatal JEV infection outcome in Indian population.
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CCL5 may contribute to promoting tumor growth, and CCL5 is a promising target that may help in understanding the pathogenesis of colorectal cancer
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an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5
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CCL5 rs2280789 G alleles were associated with higher VEGF-A levels.
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This study provided evidence that miR-146a targets CCL5 3' untranslated regions, downregulates its release from macrophages, and affects monocyte migration consequently. These findings drew a novel layer of posttranscriptional control of the chemokine CCL5 by miR-146a during HIV infection, which might contribute to HIV pathogenesis.
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Long noncoding RNA SNHG16 regulated LPS-induced inflammation injury in WI-38 cells through competitively binding miR-146a-5p with CCL5 further mediating JNK and NF-kappaB pathways, which sheds novel light on diagnostics and therapeutics in pneumonia.
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The CCL5 rs2107538 polymorphism was identified to be associated with a significantly lower risk of benign prostatic hyperplasia (BPH). This polymorphism was also associated with the development of larger prostate volumes in Chinese patients with BPH.
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This study explored the interaction of CCL5 with GPR75, an orphan receptor of the Gqalpha family of GPCRs, which appears to be expressed more abundantly in neuron-like cells than astrocytes.
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data show that a genetic variant of CCL5 confers protection against Chagas heart disease
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CCL5 deficiency could reverse obliterative changes in pulmonary arteries via caveolin-1-dependent amplification of BMPR2 signaling.
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loss of CCL5 could enhance CXCL1 expression in hepatocytes and activate CXCL1-CXCR2 axis in neutrophils to augment their hepatic infiltration
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these findings show that IL-6 and CCL5 signaling, which promote crosstalk between triple-negative breast cancer (TNBC) and lymphatic vessels, are key enhancers of TNBC tumor growth and metastasis. Furthermore, these results demonstrate that a drug combination inhibiting these pathways may be a promising therapy for TNBC patients
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CCL5/CCR5 axis may be involved in the perineural invasion of salivary adenoid cystic carcinoma cells
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In burn wounds, RANTES/CCL5 levels were on average 14.86pg/ml in young vs 4.26pg/ml in aged (p=0.026).
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Combination of IP-10 and RANTES could be potentially used as diagnostic and monitoring biomarker in pulmonary tuberculosis management.