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anti-Human FOXP3 Anticorps:
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Human Polyclonal FOXP3 Primary Antibody pour ChIP, ICC - ABIN153182
Andersson, Boasso, Nilsson, Zhang, Shire, Lindback, Shearer, Chougnet: The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients. dans Journal of immunology (Baltimore, Md. : 1950) 2005
Show all 15 Pubmed References
Human Polyclonal FOXP3 Primary Antibody pour ICC, FACS - ABIN188539
Grant, Jung, Johnson, Kostakoglu, Hsi, Byrd, Jones, Leonard, Martin, Cheson: A phase 2 trial of extended induction epratuzumab and rituximab for previously untreated follicular lymphoma: CALGB 50701. dans Cancer 2013
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Human Polyclonal FOXP3 Primary Antibody pour IHC (p) - ABIN3042405
Li, Ren, Wang, Gu, Hu, Ren, Hong, Wu, Liu, Li: T2 enhances in situ level of Foxp3+ regulatory cells and modulates inflammatory cytokines in Crohn's disease. dans International immunopharmacology 2014
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Human Polyclonal FOXP3 Primary Antibody pour WB - ABIN3043158
Fu, Li, Yang, Gai, Jia, Lei, Li: FOXP3 and TLR4 protein expression are correlated in non-small cell lung cancer: implications for tumor progression and escape. dans Acta histochemica 2013
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Mouse (Murine) Monoclonal FOXP3 Primary Antibody pour ICC, IHC - ABIN1169339
Lan, Wang, Raimondi, Wu, Colvin, de Creus, Thomson: "Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig. dans Journal of immunology (Baltimore, Md. : 1950) 2006
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Human Polyclonal FOXP3 Primary Antibody pour ICC, IF - ABIN153185
Ostroukhova, Qi, Oriss, Dixon-McCarthy, Ray, Ray: Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta. dans The Journal of clinical investigation 2006
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Human Polyclonal FOXP3 Primary Antibody pour FACS, IHC (p) - ABIN389295
Eisenberger, Seifried, Patey, Kappeler, Noel, Frey, Körner: FoxP3 positive T cells in graft biopsies from living donor kidney transplants after donor-specific transfusions. dans Transplantation 2009
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Polyclonal FOXP3 Primary Antibody pour IHC (fro), WB - ABIN540719
Ochando, Yopp, Yang, Garin, Li, Boros, Llodra, Ding, Lira, Krieger, Bromberg: Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells. dans Journal of immunology (Baltimore, Md. : 1950) 2005
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Polyclonal FOXP3 Primary Antibody pour WB - ABIN540720
Lim, Hillsamer, Banham, Kim: Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells. dans Journal of immunology (Baltimore, Md. : 1950) 2005
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Polyclonal FOXP3 Primary Antibody pour FACS, IP - ABIN540415
Polanczyk, Carson, Subramanian, Afentoulis, Vandenbark, Ziegler, Offner: Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment. dans Journal of immunology (Baltimore, Md. : 1950) 2004
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analysis of Foxp3-based immunoregulation and autoimmunity in zebrafish
correlation between the expression of t-bet, stat6 and foxp3 with other genes involved in Th and T(reg) responses
cloning and characterization of the full-length cDNA of Atlantic salmon Foxp3, which possesses a Forkhead domain, a zinc finger domain and a leucine-zipper domain as its counterpart in mammals
The increased expression of FOXP3, CTLA-4 and GITR represent higher activity of Treg cells.
Both CCL1 and CCL22 were expressed in most breast cancer tissues. CCL1 was significantly over-expressed in invasive breast cancer as compared to normal breast tissue. CCL1, but surprisingly not CCL22, showed a significant correlation with the number of tumor-infiltrating FoxP3+ Treg
Breast cancer CD4, FOXP3, and CXCL13 contents were evaluated using quantitative real-time polymerase chain reaction (qRT-PCR), and their influence on distant disease-free survival (DDFS) was examined using univariable and multivariable Cox regression and Kaplan-Meier estimates in the entire cohort and in selected molecular subgroups.
review article: propose a model whereby modulations in metabolic programming lead to changes in DNA methylation at the Foxp3 locus to allow Foxp3 expression following the reversal of anergy.
Study suggests that asthma is significantly associated with higher differentially methylated regions within the promoter region of Foxp3 and positively linked with average exposure to CO,NO2, and PM2.5 during the 90 days prior to the blood draw.
There was a significant positive correlation between the expression of EBI3 and Foxp3 mRNA in the sarcoidosis group (r=0.786, P<0.001). Conclusion: IL-35 may be involved in the inflammatory process of sarcoidosis and play an important role in the pathogenesis of the disease.
TGF-b, IL-10, and Foxp3 mRNA levels were significantly higher in patients with breast cancer than in healthy controls (P < 0.05). In summary, our results suggest that nutritional status, especially BMI, may strongly affect systematic immune function in patients with breast cancer
FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing
Results are in line with the hypothesis that in the early phase of ALS, neuroprotective helper T cells infiltrate in the affected areas in the lumbar spinal cord. This was reflected in higher peripheral percentage of CD4(+) helper T cells and higher expression of FOXP3 and IL-2Ralpha.
RUNX3, a CD8(+) lineage-specific transcription factor, binds at the FOXP3-promoter to induce its transcription.
Multivariate analysis of OS only found CD8(+)/Foxp3(+) ratio to be independent prognostic factor (P = 0.022) om spinal chordoma.
Treg cells from asthmatic patients expressed more FOXP3 as well as GATA3; the expression level of GATA3 negatively correlated with FEV1%pred. Increased expressions of USP21 and PIM2 in Treg cells from asthmatic patients were found.
Authors have demonstrated that excessive amounts of STAT5 may bind more TET2 to the FOXP3-TSDR and upregulate FOXP3 expression via DNA demethylation. Study improved the mechanism of FOXP3-TSDR hypomethylation in tumor-infiltrating CD4(+) T cells of CRC patients.
Early-pregnancy decidual mRNA expression of the regulatory T-cell marker, FOXP3, was sixfold lower (p < 0.01) in pregnancies with a male fetus compared to pregnancies with a female fetus.
In conclusion we suggest that genetic variants in FOXP3 gene may contribute to the pathogenesis of preeclampsia.
Data show that the forkhead Box Protein P3 (FOXP3) response element at the -310 bp region, but not the -2182 bp region, is mainly required for ubiquitin conjugating enzyme 9 (UBC9) activation by FOXP3.
The results suggested that increased methylation of Foxp3 Treg-specific demethylated region sequence and altered Helios gene expression in peripheral whole blood may have a role in the pathogenesis of rheumatoid arthritis via their effects on Regulatory T cell stability.
The concurrent overexpression of FoxM1 and FoxP3 was evident in gastric cancer and inversely correlated with patient survival.
Results suggest that -924A/G and +459T/C polymorphisms of the FOXP3 gene might be associated with unexplained recurrent spontaneous abortions (URSA) and -20G/A polymorphism is likely to be rare in Indian population and might not be associated with URSA.
mutations can cause early-onset insulin-requiring diabetes with or without other features of IPEX syndrome
Induction of CD4(+)CD25(+)FOXP3(+) regulatory T cells by mesenchymal stem cells is associated with modulation of ubiquitination factors and Treg-specific demethylated region demethylation.
Overall, these findings contribute to our understanding of the molecular mechanisms underlying the process of Foxp3 induction and may provide a rational basis for generating phenotypically and functionally stable iTreg cells.
Here we focus on the cytokines implicated in thymic development of Treg(T lymphocytes (Treg) expressing the transcription factor Foxp3), with a particular emphasis on the roles of interleukin-2 and IL-15
It has been shown that T-cell receptors-activated post-translational modification by O-linked N-Acetylglucosamine stabilizes FOXP3 and activates STAT5, thus integrating these critical signaling pathways.
This study demonstrated that adoptive transfer of CD4(+)CD25(+) Tregs can decrease mouse enteritis. Foxp3 expression may be improved through the Smad3 and NFAT2 signalling pathways.
the strength of TCR stimulation is a key factor for induction of the demethylation of Foxp3 conserved non-coding sequence 2 and the generation of stable Tregs
Stable Foxp3 expression in extrathymically induced regulatory T cells (iTreg) requires Forkhead box protein P1 (Foxp1). Foxp1 binds a promoter region and genetic elements, including three CNSs (CNS1-3) downstream of the transcriptional start site of Foxp3 to preserve permissive histone modifications.
Epigenetic modification is also thought to take essential part into the upregulation of Foxp3 from naive CD4 + Tcells.
Foxp3 vaccine promotes an immune response against tumor.
Unexpectedly, although dispensable for FOXP3 expression and for the homeostasis and suppressive function of thymus-derived Treg cells, CREB negatively regulates the survival of TGF-beta-induced Treg cells, and deletion of CREB resulted in increased FOXP3+ Treg cells in the intestine and protection in a colitis model
This study reports on systematic alanine-scan mutagenesis of FoxP3, assessing mutational impacts on DNA binding and transcriptional activation or repression.
Foxp3 is essential for beneficial outcome of the microglial response and depends upon signalling by the immunoglobulin CD200 through its receptor (CD200R)
Tbet is a critical modulator of FoxP3 expression in autoimmune graft-versus-host disease
Generation of RORgammat(+) antigen-specific T17 regulatory cells from Foxp3(+) precursors in autoimmunity has been described.
KLRG1 expression identifies short-lived Foxp3(+) Treg effector cells with functional plasticity in islets of NOD mice.
Novel regulatory T-cells that are induced by B cells and do not express Foxp3 and IL-10 alleviate intestinal inflammation in vivo.
the findings suggested that excreted-secreted antigens restricted Foxp3 expression by inhibiting TGFssRII/Smad2/Smad3/Smad4 signalling, ultimately resulting in abortion.
Data (including data from studies using transgenic mice) suggest that a single oral dose of vitamin A (1) amplifies tolerogenic activity of dendritic cells migrating to lymphoid tissue and (2) up-regulates expression of Foxp3 and Cd44 in co-cultures of dendritic cells and CD4+ lymphocytes. (Foxp3 = forkhead box P3; Cd44 = homing receptor)
Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity.
sequenced the entire Foxp3 cDNA which is 1296 nucleotides in length and codes for a polypeptide of 432 amino acids
In a miniature swine lung transplantation model, the FOXP3 mRNA level in the peripheral blood was upregulated at an early phase of rejection
GWAS identified a maternal variant in the upstream region of FOXP3 that was associated with infertility in repeat-breeding Japanese Black cattle that failed to conceive using embryo transfer. The variant affected the level of FOXP3 mRNA expression.
Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 and CTLA4.
regulatory role in intramuscular fat deposition
The expression of Foxp3 in CD4(+) T cells from persistent lymphocytotic cattle was significantly increased.
There is a positive correlation between the intensity of CD25 expression and the expression of the transcription Foxp3 factor in bovine CD8(+) cells.
identification of Foxp3 expression in Treg cells
These findings revealed that despite the existence of a distinct bovine CD4(+)CD25(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population
The correlation of TH17-related TLR4 expression and Foxp3-positive cells in the rectal tissue of horses with inflammatory bowel disease is reported.
Expression levels of FOXP3 mRNA copy numbers were significantly increased in lesional compared to tumour-distant samples. There was no difference in FOXP3 expression in tumour-distant samples from equine sarcoid- compared with control horses.
results confirm FoxP3 expression in the horse, in contrast to the mouse, is regulated similarly to FOXP3 expression in humans and provide evidence that FoxP3 expression by conventional T cells may help regulate the developing immune response
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
forkhead box protein P3
, regulatory protein Foxp3
, forkhead box P3
, forkhead box protein P3-like
, transcription factor foxp3
, immune dysregulation, polyendocrinopathy, enteropathy, X-linked
, immunodeficiency, polyendocrinopathy, enteropathy, X-linked
, forkhead/winged helix transcription factor 3