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anti-Human MEOX1 Anticorps:
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Human Polyclonal MEOX1 Primary Antibody pour WB - ABIN1881549
Petropoulos, Gianakopoulos, Ridgeway, Skerjanc: Disruption of Meox or Gli activity ablates skeletal myogenesis in P19 cells. dans The Journal of biological chemistry 2004
Meox1 initiates G2 cell-cycle arrest within muscle stem cells, and disrupting this G2 arrest causes premature lineage commitment and the resulting defects in muscle growth.
study reveals the molecular basis for a novel somite lineage restriction mechanism (controlled by meox1) and defines a new paradigm in induction of definitive hematopoietic stem cells
MEOX1 is a clinically relevant novel target in BCSCs and mesenchymal-like cancer cells in PTEN-deficient trastuzumab resistant breast cancer and may serve as target for future drug development.
The G > A p.Q84X mutation in the MEOX1 is identified in Klippel-Feil syndrome (Montrer GDF6 Anticorps).
We describe a multiplex consanguineous family in which isolated KFS (Montrer GDF6 Anticorps) maps to a single 17q21.31 locus that harbors a homozygous frameshift deletion in MEOX1; this deletion results in complete instability of the transcript
The results demonstrate that MEOX1 is a critical target gene and cofactor of PBX1 (Montrer PBX1 Anticorps) in ovarian cancers.
No mutations were identified in the PAX1 (Montrer PAX1 Anticorps) and MEOX1 exons or flanking intronic sequences, excluding them as likely causative genes for diaphanospondylodysostosis
MEOX1 and MEOX2 (Montrer MEOX2 Anticorps) activate p16(INK4a) in a DNA binding dependent manner, whereas they induce p21(CIP1/WAF1 (Montrer CDKN1A Anticorps)) in a DNA binding independent manner.
Meox1 expression is downregulated in the second arch of Hoxa2 (Montrer HOXA2 Anticorps) mouse mutant embryos.
Results demonstrate that Meox1 and Meox2 (Montrer MEOX2 Anticorps) genes function together and upstream of several genetic hierarchies that are required for the development of somites.
Data show that Meox1 activates the Bapx1 (Montrer NKX3-2 Anticorps) promoter in a dose-dependent manner and that this activity is enhanced in the presence of Pax1 (Montrer PAX1 Anticorps) and/or Pax9 (Montrer PAX9 Anticorps).
Meox and Gli (Montrer GLI1 Anticorps) have roles in skeletal myogenesis
Data sugges that Meox1 is part of a regulatory circuit that serves an essential, non-redundant function in the maintenance of rostro-caudal (Montrer CAD Anticorps) sclerotome polarity and axial skeleton formation.
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described.
Mox-1 related protein
, homeobox protein MOX-1
, mesenchyme homeo box 1
, mesenchyme homeobox 1
, Homeobox protein MOX-1