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Data show in fragile X mental retardation syndrome 1 protein (Fmr1) knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, leading to excessive production of ADCY1 protein and insensitivity to neuronal stimulation.
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data indicate that ST034307 is a selective small-molecule inhibitor of AC1 and suggest that selective AC1 inhibitors may be useful for managing pain.
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Genetic deletion of AC8 (adenylyl cyclase 8) but not AC1 abolished long-lasting anxiety.
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Following ethanol administration, phosphorylation of TrkB is significantly increased in the striatum of Adcyl1 and Adcyl6 knock-out mice.
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Findings provide evidence to link activation of alpha7 nAChRs to a cAMP rise via AC1, which defines a new signaling pathway employed by alpha7 nAChRs
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Results indicate that thalamic AC1 plays a major role in patterning and refinement of the mouse thalamocortical circuitry
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Adenylyl cyclase-mediated effects contribute to increased isoprenaline-induced cardiac contractility in TRPM4-deficient mice.
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Results demonstrate that ADCY1 has an evolutionarily conserved role in hearing.
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Data indicate that genetic ablation of RGS6 expression resulted in anxiolytic and antidepressant behavior by enhancing signaling through the 5-HT1A receptor-adenylyl cyclase (AC) axis.
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Contrast sensitivity is similarly reduced in Adcy1-/- mice.
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These results suggest that AC1 in retinal ganglion cell axons mediates the development of retinotopy and eye-specific segregation in the superior colliculus and dorsal lateral geniculate nucleus.
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The lower cAMP and AC mRNA level in hippocampus might participate in the molecular pathogenesis of ischemia/ reperfusion.
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Data demonstrate that stimulating the dopamine Dreceptor is essential in maintaining the normal rhythmic production of adenylyl cyclase 1 from transcript to enzyme activity.
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we have identified Adcy1 as a novel podocyte signaling protein that seems to have a role in compensatory physiological processes in the glomerulus.
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These results suggest a function of adenylate cyclase 1 in the formation of peripheral nerve trajectories such as branching and pruning
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AC1 has an essential role in fine patterning of the retinal map; retinal fibers from the ipsilateral and contralateral eye fail to segregate into eye-specific domains in the lateral geniculate nucleus and superior colliculus in AC1 mutant barrelless mice
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The potential role of AC1 in mediating synaptic plasticity and regulating AMPAR trafficking during barrel map development is studied using barrelless mice, mutants without AC1 activity or cortical 'barrel' maps.
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AC1 gene expression begins early in embryonic life (before E13), and its expression is much more widespread than in adults.
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A presynaptic, cell autonomous role of AC1 is demonstrated in the retina; AC1 is necessary to enact a retraction response of the retinal axons to ephrin-A5 during refinement of the retinotopic map.
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AC1 plays an important role in neuronal excitotoxicity
