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Results suggest that zebrafish may be used as a model organism to address the function of PLCepsilon 1 during the development of organs.
our study suggests that PLCE1 polymorphisms may affect its gene expression and are associated with not only esophageal cancer (EC) and gastric cancer (GC), but also, to some extent, noncardia cancer (NCC) risk in this study population.
Study found that the PLCepsilon expression was excessively upregulated in the majority of castrationresistant prostate cancer (CRPC) tissues, and PLCepsilon positivity was linked to poor progressionfree survival and overall survival. Furthermore, PLCepsilon knockdown significantly suppressed CRPC cell proliferation and invasion.
In urinary bladder cancer (UBC) specimens PLCepsilon and LDHA were demonstrated to be positively correlated at transcription levels, indicating that one of these two genes may be regulated by another. Knock-down of PLCepsilon in T24 cells by shRNA downregulated STAT3 phosphorylation and LDHA expression indicating that PLCepsilon may serve roles upstream of LDHA through STAT3 to regulate glycolysis in UBC.
Findings only provide evidence that hypomethylation-induced PLCE1 confers angiogenesis and proliferation in ESCC by activating PI-PLCepsilon-NF-kappaB signaling pathway and VEGF-C/Bcl-2 expression.
Pathogenic and likely pathogenic mutations in NPHS1, NPHS2, PLCE1 genes were identified by genetic testing of South Indian children with steroid resistant nephrotic syndrome.
PLCE1 rs2274223 variant was significantly correlated with the likelihood of esophageal cancer in East Asians.
PLCE1 role in the genetic susceptibility to dengue disease.[meta-analysis]
phospholipase Cepsilon (PLCepsilon) plays a role in neutrophilic alveolar inflammation of acute lung injury (ALI involving the alveolar epithelial cell
podocyte migration rate was increased by overexpression of WT Avil or PLCE1, or by EGF stimulation; however, this increased PMR was ameliorated by inhibition of the ARP2/3 complex, indicating that ARP-dependent lamellipodia formation occurs downstream of AVIL and PLCE1 function.
PLCE1 protein is essential for the functional development of the glomeruli at the capillary loop stage. The identification of a novel pathogenic mutation in PLCE1 gene using WES in a Saudi family with congenital nephrotic syndrome expands the existing mutation spectrum of PLCE1 gene within the Saudi population and worldwide.
PLCE1 polymorphism is associated with Gastric and esophageal cancer.
Study found that rs2274223 A>G in PLCE1 was associated with lower PLCE1 gene expression and increased gastric cancer (GC) survival. These findings support PLCE1 rs2274223 as a potential prognostic biomarker for GC survival.
we report the functional characterization of a four-nucleotide insertion/deletion variation (rs71031566 C----/CATTT) in PLCE1 that was associated with risk of developing esophageal squamous cell carcinoma
knockdown of expression of PLCe inhibits Prostate cancer cells proliferation via the PTEN/AKT signaling pathway.
the results of the multiple bioinformatic analysis contributes to a systematic understanding of the roles of PLCE1 in esophageal squamous cell carcinoma .
these results showed that the knockdown of PLCE1 may play a vital role in the control of esophageal squamous cell carcinoma.
Our results demonstrate that PLCE1 haplotypes (including rs2274223 and rs3765524) and expression combined with serum AFP level may predict postoperative outcome of HBV-related HCC patients.
high expression of both PLCE1 and PRKCA is significantly associated with poor outcomes of the patients with esophageal cancers.
rs10882379 and rs829232 SNPs in the PLCE1 gene may contribute to the esophageal squamous cell carcinoma (ESCC) susceptibility in Chinese Han population. Also the gene-gene and gene-environment interactions play a certain crucial role in the ESCC progression.
No association between PLCE1 genotype and early viremia level in dengue patients.
The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 . The second SNP rs30415957 resides in the intron of Plce1.The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1. Knockdown of Sorbs1 by siRNA attenuates the induction of differentiation marker gene Prl8a2
2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 receptors. Among the six isoforms of phospholipase C (PLC; PLCbeta, PLCgamma, PLCdelta, PLCepsilon, PLCzeta, PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac, enhances 2-AG-mediated synaptic depress...
study shed light on a novel role of PLCepsilon in wound healing and provided new therapeutic approaches to target PLCepsilon for diminishing scar formation after injury
PLCepsilon is crucial for N-butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase C epsilon.
PLCepsilon plays an important role in the pathogenesis of bronchial asthma through upregulating inflammatory cytokine production by the bronchial epithelial cells.
a new pathway for TRPC6 activation by Phospholipase C epsilon
findings reveal a pathway initiated by GPCR agonist-induced RhoA activation, in which PLCepsilon signals to PKD1-mediated phosphorylation of cytoskeletal proteins
Activity of PLCepsilon contributes to chemotaxis of fibroblasts towards PDGF.
PLCepsilon links G protein-coupled receptors (GPCR) to sustained PKD activation, providing a means for GPCR ligands that couple to RhoA to induce NF-kappaB signaling and promote neuroinflammation.
These results reveal a crucial role of PLCepsilon in the development of skin inflammation and suggest a mechanism in which PLCepsilon induces the production of cytokines including IL-23 from keratinocytes, leading to the activation of IL-22-producing T cells.
results indicate that PLCvarepsilon has a crucial role in UVB-induced acute inflammatory reactions such as neutrophil infiltration and epidermal thickening by at least in part regulating expression of CXCL1/KC in skin cells such as keratinocytes and fibroblasts
PLCepsilon may be a key molecule regulating the signal pathway of bladder cancer proliferation
Phospholipase c-epsilon is a determinant of mouse islet insulin secretion that is under the control of Epac2.
resistance to UVB-induced cell death conferred by the absence of PLCepsilon is closely related to the higher incidence of skin tumor formation.
PLCepsilon plays a crucial role in induction of proinflammatory cytokine expression in fibroblasts and keratinocytes at the challenged sites
the induction of phospholipase Cepsilon expression may be a specific event associated with the commitment of the neural precursor cells to the neuronal lineage.
Phospholipase C epsilon acts downstream of the epidermal growth factor receptor in controlling semilunar valvulogenesis through inhibition of bone morphogenetic protein signaling.
GPCR agonists ET-1, LPA, and thrombin activate PLCepsilon and PLCbeta3 in fibroblasts. Activation of these PLC isoforms displays agonist-specific temporal profiles; PLCbeta3 is predominantly involved in acute and PLCepsilon in sustained PI hydrolysis
Phospholipase Cepsilon has a role in Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome\; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
phospholipase C, epsilon 1
, pancreas-enriched phospholipase C
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1-like
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
, phosphoinositide phospholipase C-epsilon-1
, phosphoinositide-specific phospholipase C epsilon-1
, phospholipase C-epsilon-1
, phospholipase C epsilon