PLCE1 Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2729133

Détail du produit

Antigène: PLCE1 (Phospholipase C, epsilon 1 (PLCE1))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette PLCE1 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human PLCE1 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: PLCE1 (Phospholipase C, epsilon 1 (PLCE1))

Autre désignation: Plce1 (PLCE1 Produits)

Synonymes: PLCE1 Protein, NPHS3 Protein, PLCE Protein, PPLC Protein, 4933403A21Rik Protein, PLCepsilon Protein, Plce Protein, mKIAA1516 Protein, phospholipase C, epsilon 1 Protein, phospholipase C epsilon 1 Protein, PLCE1 Protein, plce1 Protein, Plce1 Protein

Sujet: This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

Poids moléculaire: 258.5 kDa

NCBI Accession: NP_057425

Pathways: EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling