ErbB2/Her2 Protéines
(Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
| Catalog no. | Produit | Reactivité | Hôte / Clonalité | Application | Prix et délai de livraison |
|---|---|---|---|---|---|
| ErbB2/Her2 Protein (AA 23-652) (His tag,Biotin) | Humain | HEK-293 Cells |
|
2.263,20 €
Voir le prix
|
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| ErbB2/Her2 Protein (AA 23-652) (Fc Tag) | Humain | HEK-293 Cells |
|
462,30 €
Voir le prix
|
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| ErbB2/Her2 Protein (AA 23-652) (His tag,AVI tag,Biotin) | Humain | HEK-293 Cells |
|
2.175,80 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-652) (His tag) | Humain | Mammalian Cells |
|
731,38 €
Voir le prix
|
|
| ErbB2/Her2 Protein (A775_G776insYVMA) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
425,54 €
Voir le prix
|
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| ErbB2/Her2 Protein (P780_Y781insGSP) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
425,54 €
Voir le prix
|
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| ErbB2/Her2 Protein (V842I) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
425,54 €
Voir le prix
|
|
| ErbB2/Her2 Protein (V956R) (His tag) | Humain | Baculovirus infected Insect Cells |
|
425,54 €
Voir le prix
|
|
| ErbB2/Her2 Protein (V777_G778insCG) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
425,54 €
Voir le prix
|
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| ErbB2/Her2 Protein (AA 755-759 deleted) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
425,54 €
Voir le prix
|
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| ErbB2/Her2 Protein (D769H) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
425,54 €
Voir le prix
|
|
| ErbB2/Her2 Protein (D769Y) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
425,54 €
Voir le prix
|
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| ErbB2/Her2 Protein (C805S) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
436,31 €
Voir le prix
|
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| ErbB2/Her2 Protein (E719G) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
425,54 €
Voir le prix
|
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| ErbB2/Her2 Protein (E719K) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
425,54 €
Voir le prix
|
|
| ErbB2/Her2 Protein (G776V) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
425,54 €
Voir le prix
|
|
| ErbB2/Her2 Protein (L755S, L869R) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
436,31 €
Voir le prix
|
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| ErbB2/Her2 Protein (R896C) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
425,54 €
Voir le prix
|
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| ErbB2/Her2 Protein (L785F) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
425,54 €
Voir le prix
|
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| ErbB2/Her2 Protein (V777L) (GST tag) | Humain | Baculovirus infected Insect Cells |
|
425,54 €
Voir le prix
|
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- Bind (Binding Studies: Image de validation disponible)
2 références - Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by reduced SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- Bind (Binding Studies: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >90 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- WB (Western Blotting: Application indiquée)
- SDS (SDS-PAGE: Application indiquée)
- Imm (Immunogen: Application indiquée)
- ELISA (ELISA: Application indiquée)
- AcA (Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Mammalian Cells
- Type Proteine
- Recombinant
- Pureté
- >90 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Activité biologique
- Active
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Activité biologique
- Active
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Activité biologique
- Active
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Activité biologique
- Active
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Activité biologique
- Active
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Activité biologique
- Active
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Activité biologique
- Active
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Activité biologique
- Active
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Activité biologique
- Active
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Activité biologique
- Active
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Activité biologique
- Active
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Activité biologique
- Active
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Activité biologique
- Active
Protein
- KAA (Kinase Activity Assay: Application indiquée)
- Origine
- Humain
- Hôte
- Baculovirus infected Insect Cells
- Type Proteine
- Recombinant
- Activité biologique
- Active
Dernières publications pour nos ErbB2/Her2 Protéines
: "Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab." dans: BMC molecular and cell biology, Vol. 21, Issue 1, pp. 2, (2020) (PubMed).
: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." dans: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).
: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." dans: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).
: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." dans: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).
: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." dans: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).
: "Isolation and characterization of camelid single-domain antibodies against HER2." dans: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).
: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." dans: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).
: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." dans: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).
: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." dans: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).
: "The Impact of FcγRI Binding on ImmunoPET." dans: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, (2019) (PubMed).
: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." dans: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).
: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." dans: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).
: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." dans: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).
: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." dans: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).
: "Isolation and characterization of camelid single-domain antibodies against HER2." dans: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).
: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." dans: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).
: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." dans: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).
: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." dans: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).
: "The Impact of FcγRI Binding on ImmunoPET." dans: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, (2019) (PubMed).
Pseudonymes pour ErbB2/Her2 Protéines
erb-b2 receptor tyrosine kinase 2 (ERBB2) Protéineserb-b2 receptor tyrosine kinase 2 (Erbb2) Protéines
erb-b2 receptor tyrosine kinase 2 (erbb2) Protéines
c-erbB2 Protéines
c-neu Protéines
CD340 Protéines
erb2 Protéines
Erbb-2 Protéines
HER-2 Protéines
HER-2/neu Protéines
HER2 Protéines
mKIAA3023 Protéines
MLN 19 Protéines
NEU Protéines
Neu Protéines
NGL Protéines
TKR1 Protéines
wu:fv70f10 Protéines
zgc:63601 Protéines
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