ErbB2/Her2 Protéines
(Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
| Catalog no. | Produit | Reactivité | Hôte / Clonalité | Application | Prix et délai de livraison |
|---|---|---|---|---|---|
| ErbB2/Her2 Protein (AA 377-579) (His tag) | Souris | Escherichia coli (E. coli) |
|
742,71 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-372) (His tag) | Humain | Escherichia coli (E. coli) |
|
687,38 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 376-578) | Humain | Escherichia coli (E. coli) |
|
763,69 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-653) (His tag) | Souris | HEK-293 Cells |
|
516,35 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-652) (His tag,AVI tag,Biotin) | Cynomolgus | HEK-293 Cells |
|
2.175,80 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 498-648) (His tag) | Humain | HEK-293 Cells |
|
516,35 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-652) (His tag,FITC) | Humain | HEK-293 Cells |
|
3.252,20 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-652) (Strep Tag) | Humain | HEK-293 Cells |
|
516,35 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-652, Extracellular) (His tag) | Humain | Escherichia coli (E. coli) |
|
515,90 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 153-598) (His tag) | Humain | Escherichia coli (E. coli) |
|
556,60 €
Voir le prix
|
|
| ErbB2/Her2 Protein (Transcript Variant 1) (DYKDDDDK-His Tag) | Humain | HEK-293 Cells |
|
1.115,38 €
Voir le prix
|
|
| ErbB2/Her2 Protein (DYKDDDDK Tag) | Humain | Insect cells (Sf9) |
|
700,00 €
Voir le prix
|
|
| ErbB2/Her2 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) | Humain | HEK-293 Cells |
|
1.077,31 €
Voir le prix
|
|
| ErbB2/Her2 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag) | Humain | HEK-293 Cells |
|
1.077,31 €
Voir le prix
|
|
| ErbB2/Her2 Protein (AA 23-654) (His tag) | Rat | Levure |
|
3.828,00 €
Voir le prix
|
|
| ErbB2/Her2 Protein (Alexa Fluor 555,His tag) | Humain | HEK-293 Cells |
|
3.713,35 €
Voir le prix
|
|
| ErbB2/Her2 Protein (His tag) | Lapin | HEK-293 Cells |
|
516,35 €
Voir le prix
|
|
| ErbB2/Her2 Protein (Alexa Fluor 647,His tag) | Humain | HEK-293 Cells |
|
3.713,35 €
Voir le prix
|
|
| ErbB2/Her2 Protein (FITC,Fc Tag) | Humain | HEK-293 Cells |
|
3.096,95 €
Voir le prix
|
|
| ErbB2/Her2 Protein (Alexa Fluor 488,His tag) | Humain | HEK-293 Cells |
|
3.713,35 €
Voir le prix
|
Protein
- WB (Western Blotting: Application indiquée)
- SDS (SDS-PAGE: Application indiquée)
- Imm (Immunogen: Application indiquée)
- PC (Positive Control: Application indiquée)
- Origine
- Souris
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
- Pureté
- > 95 %
Protein
- WB (Western Blotting: Application indiquée)
- SDS (SDS-PAGE: Application indiquée)
- Imm (Immunogen: Application indiquée)
- PC (Positive Control: Application indiquée)
- Origine
- Humain
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
- Pureté
- > 90 %
Protein
- AcA (Activity Assay: Application indiquée)
- CC (Cell Culture: Application indiquée)
- Origine
- Humain
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
- Pureté
- > 95 %
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
1 reference - Origine
- Souris
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by SDS-PAGE.
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- Origine
- Cynomolgus
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >90 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >90 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- Bind (Binding Studies: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- Origine
- Humain
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
- Pureté
- Greater than 90 % as determined by SDS-PAGE.
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- Origine
- Humain
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
- Pureté
- Greater than 90 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: Image de validation disponible)
- STD (Standard: Application indiquée)
- AbP (Antibody Production: Application indiquée)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
Protein
- WB (Western Blotting: Image de validation disponible)
- STD (Standard: Application indiquée)
- AbP (Antibody Production: Application indiquée)
- Origine
- Humain
- Hôte
- Insect cells (Sf9)
- Type Proteine
- Recombinant
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
Protein
- WB (Western Blotting: Image de validation disponible)
- STD (Standard: Application indiquée)
- AbP (Antibody Production: Application indiquée)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
Protein
- WB (Western Blotting: Image de validation disponible)
- STD (Standard: Application indiquée)
- AbP (Antibody Production: Application indiquée)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
Protein
- ELISA (ELISA: Application indiquée)
- Origine
- Rat
- Hôte
- Levure
- Type Proteine
- Recombinant
- Pureté
- > 90 %
Protein
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- 95,00 %
Protein
- Origine
- Lapin
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >95 % as determined by SDS-PAGE.
Protein
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- 90,00 %
Protein
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >90 % as determined by SDS-PAGE.
Protein
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- 95,00 %
Dernières publications pour nos ErbB2/Her2 Protéines
: "Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab." dans: BMC molecular and cell biology, Vol. 21, Issue 1, pp. 2, (2020) (PubMed).
: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." dans: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).
: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." dans: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).
: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." dans: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).
: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." dans: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).
: "Isolation and characterization of camelid single-domain antibodies against HER2." dans: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).
: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." dans: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).
: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." dans: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).
: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." dans: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).
: "The Impact of FcγRI Binding on ImmunoPET." dans: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, (2019) (PubMed).
: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." dans: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).
: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." dans: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).
: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." dans: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).
: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." dans: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).
: "Isolation and characterization of camelid single-domain antibodies against HER2." dans: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).
: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." dans: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).
: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." dans: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).
: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." dans: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).
: "The Impact of FcγRI Binding on ImmunoPET." dans: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, (2019) (PubMed).
Pseudonymes pour ErbB2/Her2 Protéines
erb-b2 receptor tyrosine kinase 2 (ERBB2) Protéineserb-b2 receptor tyrosine kinase 2 (Erbb2) Protéines
erb-b2 receptor tyrosine kinase 2 (erbb2) Protéines
c-erbB2 Protéines
c-neu Protéines
CD340 Protéines
erb2 Protéines
Erbb-2 Protéines
HER-2 Protéines
HER-2/neu Protéines
HER2 Protéines
mKIAA3023 Protéines
MLN 19 Protéines
NEU Protéines
Neu Protéines
NGL Protéines
TKR1 Protéines
wu:fv70f10 Protéines
zgc:63601 Protéines
Avez-vous cherché autre chose?
- ERAS Protéines
- ERAP2 Protéines
- ERAP1 Protéines
- ERAL1 Protéines
- ER Lipid Raft Associated 2 Protéines
- EPYC Protéines
- EPX Protéines
- EPT1 Protéines
- EPSTI1 Protéines
- Epstein-Barr Virus Nuclear Antigen-1 Protéines
- Epsin 2 Protéines
- Epsin 1 Protéines
- EPS8-Like 3 Protéines
- EPS8-Like 2 Protéines
- EPS8-Like 1 Protéines
- EPS8 Protéines
- EPS15 Protéines
- EPRS Protéines
- Eppin Protéines
- EPO Protéines
- ERBB2IP Protéines
- ERBB3 Protéines
- ERBB4 Protéines
- ERC1 Protéines
- ERCC1 Protéines
- ERCC2 Protéines
- ERCC3 Protéines
- ERCC4 Protéines
- ERCC5 Protéines
- ERCC6 Protéines
- ERCC6L Protéines
- ERCC8 Protéines
- ERF Protéines
- ERG Protéines
- ERGIC1 Protéines
- ERGIC2 Protéines
- ERGIC3 Protéines
- ERH Protéines
- ERI1 Protéines
- ERK1 Protéines
Vous êtes ici:
