MEG3 Produits
(Family with Sequence Similarity 129, Member B (FAM129B))
Catégories
MEG3 (Maternally Expressed Gene 3) is a long non-coding RNA (lncRNA) that is part of the DLK1-MEG3 locus on chromosome 14q32.3. This locus is imprinted, meaning that genes from only one parental allele are expressed while the other allele is silenced. Specifically, MEG3 is maternally expressed and paternally silenced.
- Tumor Suppressor: MEG3 has been identified as a tumor suppressor in various types of cancers. Its expression is often downregulated in tumor tissues compared to normal tissues. The loss of MEG3 expression has been associated with tumor progression and poor prognosis in several cancers.
- Regulation of Cell Proliferation and Apoptosis: MEG3 plays a role in controlling cell proliferation and promoting apoptosis. Its downregulation can lead to increased cell proliferation and reduced apoptosis, which can contribute to tumorigenesis.
- Modulation of p53 Pathway: MEG3 can enhance the activity of the p53 protein, a critical tumor suppressor. By modulating the p53 pathway, MEG3 can influence cell cycle arrest, apoptosis, and DNA repair.
- Role in Neural Development: Apart from its role in cancer, MEG3 is also involved in neural development. It is expressed in the brain and has been implicated in the differentiation of neural stem cells.
- Interaction with Other Molecules: As an lncRNA, MEG3 can interact with various molecules in the cell, including proteins, other RNAs, and DNA. These interactions can influence gene expression, protein activity, and cellular functions.
- Epigenetic Regulation: MEG3 is involved in the epigenetic regulation of genes. It can recruit chromatin-modifying enzymes to specific genomic regions, leading to changes in gene expression.
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Catégories MEG3 en vedette
MEG3 Anticorps
High quality antibodies with extensive validation data.
MEG3 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
MEG3 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF, ELISA
Validations
- (2)
N° du produit
ABIN7138336
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (2)
N° du produit
ABIN7114073
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB
Validations
- (1)
N° du produit
ABIN6254107
Quantité
100 μL
Fiche technique
Fiche technique
MEG3 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6230630
Quantité
96 tests
Fiche technique
Fiche technique
MEG3 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
- (1)
N° du produit
ABIN3075684
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
- (1)
N° du produit
ABIN3084514
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
N° du produit
ABIN3126619
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits MEG3
: "Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163." dans: Tumour biology, Vol. 37, Issue 3, pp. 3925-31, (2016) (PubMed).: "Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway." dans: American journal of translational research, Vol. 8, Issue 2, pp. 1091-9, (2016) (PubMed).
: "FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells." dans: F1000Research, Vol. 2, pp. 134, (2014) (PubMed).
Synonymes et noms alternatifs relatifs à MEG3
family with sequence similarity 129 member B (FAM129B), family with sequence similarity 129 member B S homeolog (fam129b.S), family with sequence similarity 129 member B (fam129b), family with sequence similarity 129, member B (Fam129b), family with sequence similarity 129, member Ba (fam129ba), 9130404D14Rik, bA356B19.6, C9orf88, fam129b, MEG-3, MGC82535, MINERVA, OC58, RGD1307018, zgc:158319Protein level used designations for MEG3
- melanoma invasion by ERK
- niban-like protein 1
- family with sequence similarity 129, member B
- hypothetical protein LOC100145245
- Niban-like protein 1
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