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anti-Human NR4A1 Anticorps:
anti-Mouse (Murine) NR4A1 Anticorps:
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Human Polyclonal NR4A1 Primary Antibody pour ChIP, ICC - ABIN252681
Nakai, Kartha, Sakurai, Toback, DeGroot: A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. dans Molecular endocrinology (Baltimore, Md.) 1991
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Mouse (Murine) Monoclonal NR4A1 Primary Antibody pour WB - ABIN967395
Davis, Hazel, Chen, Blenis, Lau: Functional domains and phosphorylation of the orphan receptor Nur77. dans Molecular endocrinology (Baltimore, Md.) 1993
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Cow (Bovine) Polyclonal NR4A1 Primary Antibody pour IHC, WB - ABIN2782269
Smith, Luk, Newton, Roberts, Sturm, Muscat: Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells. dans The Journal of biological chemistry 2008
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Human Polyclonal NR4A1 Primary Antibody pour ELISA, IHC (p) - ABIN188670
Kiss, Oskolás, Tóth, Bouillet, Tóth, Fülöp, Scholtz, Ledent, Fésüs, Szondy: Adenosine A2A receptor-mediated cell death of mouse thymocytes involves adenylate cyclase and Bim and is negatively regulated by Nur77. dans European journal of immunology 2006
Cow (Bovine) Polyclonal NR4A1 Primary Antibody pour IHC, WB - ABIN2777511
Lu, Suzuki, Yoshikawa, Murakami, Miki, Moriya, Bassett, Rainey, Hayashi, Sasano: Nur-related factor 1 and nerve growth factor-induced clone B in human adrenal cortex and its disorders. dans The Journal of clinical endocrinology and metabolism 2004
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we show here that the BCR (Montrer BCR Anticorps)/BTK (Montrer BTK Anticorps) target gene NR4A1 is a potential oncogene (Montrer RAB1A Anticorps) in mantle cell lymphoma
this study confirmed that NR4A1 sensitizes gastric cancer cells to TNFalpha (Montrer TNF Anticorps)-induced apoptosis through the inhibition of JNK (Montrer MAPK8 Anticorps)/Parkin (Montrer PARK2 Anticorps)-dependent mitophagy.
Inhibition of NR4A1 in stromal cells increased the TGF-beta1 (Montrer TGFB1 Anticorps)-dependent elevated expression of fibrotic markers, and loss of NR4A1 stimulated fibrogenesis in mice with endometriosis.
NR4A1 knockdown partly decreased surface NR2B (Montrer GRIN2B Anticorps) by promoting NR2B (Montrer GRIN2B Anticorps) internalization.
Data show that SUMOylation is critical in controlling NR4A1 function in inflammatory cytokine signaling and controlling macrophage cell death.
our findings suggest that hypoxia-induced down-regulation of TR3 might play an important role for hypoxia-induced apoptosis resistance in NSCLC.
Nur77 suppresses CD4 (Montrer CD4 Anticorps)(+) T cell proliferation and uncover a suppressive role for Irf4 (Montrer IRF4 Anticorps) in TH2 polarization; halving Irf4 (Montrer IRF4 Anticorps) gene-dosage leads to increases in GATA3 (Montrer GATA3 Anticorps)(+) and IL-4 (Montrer IL4 Anticorps)(+) cells.
our data demonstrated that NR4A1 protein physically associates with the WT1 (Montrer WT1 Anticorps) promoter, and enhanced WT1 (Montrer WT1 Anticorps) promoter transactivation and knockdown of WT1 (Montrer WT1 Anticorps) in MIN6 cells induced apoptosis. These findings suggest that NR4A1 protects pancreatic beta-cells against H2O2 mediated apoptosis by up-regulating WT1 (Montrer WT1 Anticorps) expression.
NR4A modulates the decidualization of hESCs by upregulating prolactin (PRL (Montrer PRL Anticorps)) and insulin-like growth factor binding protein-1 (IGFBP-1 (Montrer IGFBPI Anticorps)) expression and transformation in vitro.
DNMT1 (Montrer DNMT1 Anticorps) causes NR4A1 DNA hypermethylation and blocks insulin (Montrer INS Anticorps) signaling in an Chinese patients with type 2 diabetes
Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells.
we found that either knockdown of Nr4a1 or 3, 3'- Diindolylmethane (DIM), an Nr4a1 antagonist, were able to rescue the effects of SNRPN (Montrer SNRPN Anticorps) knockdown on neurite outgrowth of embryonic cortical neurons, providing the potential therapeutic methods for SNRPN (Montrer SNRPN Anticorps) deletion disorders. We thus concluded that maintaining the proper level of SNRPN (Montrer SNRPN Anticorps) is critical in cortical neurodevelopment.
new insights into the understanding the mechanisms of the effects of Nur77 on LPS (Montrer TLR4 Anticorps)-activated microglia
These results suggest that berberine-induced activation of AMPK (Montrer PRKAA1 Anticorps) may contribute to hepatic FGF21 (Montrer FGF21 Anticorps) expression via NUR77.
we found that KLF6 (Montrer KLF6 Anticorps) transcriptionally cooperates with NUR77 and SF1 (Montrer SF1 Anticorps)
Ca(2 (Montrer CA2 Anticorps)+) signaling pathway increases Nr4a1 expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (Montrer MEF2C Anticorps), AP1 (Montrer JUN Anticorps), and CREB (Montrer CREB1 Anticorps) transcription factors thus demonstrating an important interplay between the Ca(2 (Montrer CA2 Anticorps)+) and cAMP pathways in regulating Nr4a1 expression.
additional loss of Nur77 in the absence of Bim (Montrer BCL2L11 Anticorps) led to diabetes induction, suggesting that Nur77 promotes tolerance in this context. Together, these data reveal novel nondeletional roles for Nur77 that differ between T cell subsets and have implications for self-tolerance.
current data identify Nr4a1 as regulator of microglia activation and potentially new target for the treatment of inflammatory CNS diseases such as multiple sclerosis.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, TR3 orphan receptor
, early response protein NAK1
, growth factor-inducible nuclear protein N10
, hormone receptor
, nerve growth factor IB nuclear receptor variant 1
, nuclear hormone receptor NUR/77
, nuclear receptor subfamily 4 group A member 1
, orphan nuclear receptor HMR
, orphan nuclear receptor TR3
, steroid receptor TR3
, testicular receptor 3
, orphan nuclear receptor NGFI-B
, nuclear protein N10
, Orphan nuclear receptor HMR
, immediate early gene transcription factor NGFI-B
, nerve growth factor induced protein I-B
, nerve growth factor-induced protein I-B