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Human Polyclonal NR4A1 Primary Antibody pour ChIP, ICC - ABIN252681
Nakai, Kartha, Sakurai, Toback, DeGroot: A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. dans Molecular endocrinology (Baltimore, Md.) 1991
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Mouse (Murine) Monoclonal NR4A1 Primary Antibody pour WB - ABIN967395
Davis, Hazel, Chen, Blenis, Lau: Functional domains and phosphorylation of the orphan receptor Nur77. dans Molecular endocrinology (Baltimore, Md.) 1993
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Human Polyclonal NR4A1 Primary Antibody pour ELISA, IHC (p) - ABIN188670
Kiss, Oskolás, Tóth, Bouillet, Tóth, Fülöp, Scholtz, Ledent, Fésüs, Szondy: Adenosine A2A receptor-mediated cell death of mouse thymocytes involves adenylate cyclase and Bim and is negatively regulated by Nur77. dans European journal of immunology 2006
Cow (Bovine) Polyclonal NR4A1 Primary Antibody pour IHC, WB - ABIN2782269
Smith, Luk, Newton, Roberts, Sturm, Muscat: Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells. dans The Journal of biological chemistry 2008
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Cow (Bovine) Polyclonal NR4A1 Primary Antibody pour IHC, WB - ABIN2777511
Lu, Suzuki, Yoshikawa, Murakami, Miki, Moriya, Bassett, Rainey, Hayashi, Sasano: Nur-related factor 1 and nerve growth factor-induced clone B in human adrenal cortex and its disorders. dans The Journal of clinical endocrinology and metabolism 2004
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Inhibition of NR4A1 in stromal cells increased the TGF-beta1 (Montrer TGFB1 Anticorps)-dependent elevated expression of fibrotic markers, and loss of NR4A1 stimulated fibrogenesis in mice with endometriosis.
NR4A1 knockdown partly decreased surface NR2B (Montrer GRIN2B Anticorps) by promoting NR2B (Montrer GRIN2B Anticorps) internalization.
Data show that SUMOylation is critical in controlling NR4A1 function in inflammatory cytokine signaling and controlling macrophage cell death.
our findings suggest that hypoxia-induced down-regulation of TR3 might play an important role for hypoxia-induced apoptosis resistance in NSCLC.
Nur77 suppresses CD4 (Montrer CD4 Anticorps)(+) T cell proliferation and uncover a suppressive role for Irf4 (Montrer IRF4 Anticorps) in TH2 polarization; halving Irf4 (Montrer IRF4 Anticorps) gene-dosage leads to increases in GATA3 (Montrer GATA3 Anticorps)(+) and IL-4 (Montrer IL4 Anticorps)(+) cells.
our data demonstrated that NR4A1 protein physically associates with the WT1 (Montrer WT1 Anticorps) promoter, and enhanced WT1 (Montrer WT1 Anticorps) promoter transactivation and knockdown of WT1 (Montrer WT1 Anticorps) in MIN6 cells induced apoptosis. These findings suggest that NR4A1 protects pancreatic beta-cells against H2O2 mediated apoptosis by up-regulating WT1 (Montrer WT1 Anticorps) expression.
NR4A modulates the decidualization of hESCs by upregulating prolactin (PRL (Montrer PRL Anticorps)) and insulin-like growth factor binding protein-1 (IGFBP-1 (Montrer IGFBPI Anticorps)) expression and transformation in vitro.
DNMT1 (Montrer DNMT1 Anticorps) causes NR4A1 DNA hypermethylation and blocks insulin (Montrer INS Anticorps) signaling in an Chinese patients with type 2 diabetes
Data show that nuclear receptor 4A1 (NR4A1) knockdown and the C-DIM/NR4A1 antagonists were comparable as inhibitors of NR4A1-dependent genes/pathways.
mRNAs expression and methylation pattern of RARB (Montrer RARB Anticorps), NR4A1 and HSD3B2 (Montrer HSD3B2 Anticorps) genes in human adrenal tissues (HAT (Montrer MGEA5 Anticorps)) and in pediatric virilizing adrenocortical tumors (VAT) were analyzed.
Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells.
new insights into the understanding the mechanisms of the effects of Nur77 on LPS (Montrer TLR4 Anticorps)-activated microglia
These results suggest that berberine-induced activation of AMPK (Montrer PRKAA1 Anticorps) may contribute to hepatic FGF21 (Montrer FGF21 Anticorps) expression via NUR77.
we found that KLF6 (Montrer KLF6 Anticorps) transcriptionally cooperates with NUR77 and SF1 (Montrer SF1 Anticorps)
Ca(2 (Montrer CA2 Anticorps)+) signaling pathway increases Nr4a1 expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (Montrer MEF2C Anticorps), AP1 (Montrer JUN Anticorps), and CREB (Montrer CREB1 Anticorps) transcription factors thus demonstrating an important interplay between the Ca(2 (Montrer CA2 Anticorps)+) and cAMP pathways in regulating Nr4a1 expression.
additional loss of Nur77 in the absence of Bim (Montrer BCL2L11 Anticorps) led to diabetes induction, suggesting that Nur77 promotes tolerance in this context. Together, these data reveal novel nondeletional roles for Nur77 that differ between T cell subsets and have implications for self-tolerance.
current data identify Nr4a1 as regulator of microglia activation and potentially new target for the treatment of inflammatory CNS diseases such as multiple sclerosis.
Celastrol promotes Nur77 migration from the nucleus to mitochondria, where it is ubiquitinated by TRAF2 (Montrer TRAF2 Anticorps). Ubiquitinated Nur77 then interacts with p62/SQSTM1 (Montrer SQSTM1 Anticorps), leading to autophagy of dysfunctional mitochondria and alleviation of inflammation.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, TR3 orphan receptor
, early response protein NAK1
, growth factor-inducible nuclear protein N10
, hormone receptor
, nerve growth factor IB nuclear receptor variant 1
, nuclear hormone receptor NUR/77
, nuclear receptor subfamily 4 group A member 1
, orphan nuclear receptor HMR
, orphan nuclear receptor TR3
, steroid receptor TR3
, testicular receptor 3
, orphan nuclear receptor NGFI-B
, nuclear protein N10
, Orphan nuclear receptor HMR
, immediate early gene transcription factor NGFI-B
, nerve growth factor induced protein I-B
, nerve growth factor-induced protein I-B