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anti-Mouse (Murine) DACH1 Anticorps:
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Human Polyclonal DACH1 Primary Antibody pour ICC, IF - ABIN4304211
Powe, Dhondalay, Lemetre, Allen, Habashy, Ellis, Rees, Ball: DACH1: its role as a classifier of long term good prognosis in luminal breast cancer. dans PLoS ONE 2014
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Human Polyclonal DACH1 Primary Antibody pour ELISA, WB - ABIN314239
Wu, Yang, Wang, Davoli, DAmico, Li, Cveklova, Kozmik, Lisanti, Russell, Cvekl, Pestell: DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. dans The Journal of biological chemistry 2003
HDAC4 (Montrer HDAC5 Anticorps)-mediated SUMOylation of the corepressor DACH1 is decreased, which protects DACH1 from proteasomal degradation
The results of this study suggested the involvement of the mouse Dach1 gene in adult neurogenesis; cells expressing this gene exhibit the properties of adult NSCs or neuroblasts and respond to MCAo by enhanced neurogenesis.
find that in cells growing in IGF-1 (Montrer IGF1 Anticorps) (and unresponsive to EGF (Montrer EGF Anticorps)), DACH1 is devoid of tumor suppressor activity
The mouse dachshund gene is related to the Ski (Montrer SKI Anticorps) proto-oncogene (Montrer RAB1A Anticorps) and is expressed in eye and limb.
In the mouse, Dach1 expression in the developing ear also overlaps with the expression of Eya1 (Montrer EYA1 Anticorps) (an eya homologue)
Dach1 is a target gene of FGF signaling during limb skeletal development, and Dach1 may function as an intermediary in the FGF signaling pathway regulating cell proliferation or differentiation
Dach1 is critical for postnatal survival of mice
The phosphatase function of Eya switches the function of Six1 (Montrer SIX1 Anticorps)-Dach from repression to activation, causing transcriptional activation through recruitment of co-activators
The Pax (Montrer PXN Anticorps)-Eya-Six-Dach network is at best only partly conserved during lens and nasal placode development.
DACH1 repressed cyclin D1 (Montrer CCND1 Anticorps) through a novel mechanism via a c-Jun (Montrer JUN Anticorps) DNA-binding partner, requiring the DACH1 alpha-helical DS domain which recruits corepressors to the local chromatin.
Knockdown of DACH1 expression can remarkably enhance the cell apoptosis, restrain the proliferation, migration and invasion of Capan-1 cells.
DACH1 expression regulates the pancreatic cancer cell apoptosis.
Low DACH1 expression is associated with invasion of lung adenocarcinoma.
This study concludes that MiR (Montrer MLXIP Anticorps)-217 is the upstream regulator of PGC-1alpha (Montrer PPARGC1A Anticorps) in breast cancer regulation in vitro, possibly independent of DACH1 signaling pathway.
Kaplan-Mier analysis of human NSCLC samples demonstrated that high DACH1 mRNA levels predicted favorable prognosis for relapse-free and overall survival. In agreement, high CXCL5 (Montrer CXCL5 Anticorps) expression predicted a worse prognosis for survival.
DACH1 expression was reduced in hepatocellular carcinoma even at early stage and associated with tumor progression. Overexpression inhibited HCC (Montrer FAM126A Anticorps) cell growth and migration by inactivating the Wnt (Montrer WNT2 Anticorps) pathway via GSK3beta (Montrer GSK3b Anticorps) phosphorylation to suppress beta-catenin (Montrer CTNNB1 Anticorps).
In breast cancer, some GATA3 (Montrer GATA3 Anticorps) effects shift from tumor suppressing to tumor promoting during tumorigenesis, with deregulation of three genes, BCL2 (Montrer BCL2 Anticorps), DACH1, THSD4, representing major GATA3 (Montrer GATA3 Anticorps)-controlled processes in cancer progression.
Results indicated that DACH1 was a novel molecular marker of RCC (Montrer XRCC1 Anticorps) and it attributed to the malignant behavior of renal cancer cells.
Data indicate that dachshund family transcription factor 1 (Montrer HNF1A Anticorps) (DACH1) suppresses gastric cancer cell proliferation, invasion and metastasis by inhibiting transforming growth factor beta (TGF-beta) signalling pathways both in vitro and in vivo.
results suggest that DACH1 loss of function results in increased cell growth, motility and invasiveness through TGF-beta (Montrer TGFB1 Anticorps)-mediated EMT (Montrer ITK Anticorps), and DACH1 loss of function has important therapeutic implications for targeted therapies of CRC (Montrer CALR Anticorps)
This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene.
dachshund homolog 1 (Drosophila)
, dachshund homolog 1
, dachshund 1
, dachshund protein
, dachshund homolog 1-like