AEE788

Détails pour le produit réf. ABIN3219845
Application
Inhibition Assay (InhA), Functional Studies (Func)
Options
Fonction AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.
Attributs du produit Target: EGFR inhibitor, Bcr-Abl inhibitor, Src inhibitor, HER2 inhibitor
Receptor: EGFR/c-Abl/FLT1/c-Src, HER2/ErbB2, HER4/ErbB4
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Pureté 98 %
Formula C27H32N6
Solubility 100 mM in DMSO
Sujet Tyrosine Kinase/Adaptors
Poids moléculaire 440.58 g/mol
Numéro CAS 497839-62-0
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Stock -20 °C
Stockage commentaire For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Date de péremption 24 months