Cabozantinib (XL184, BMS-907351)

Détails pour le produit réf. ABIN3220300
Application
Inhibition Assay (InhA), Functional Studies (Func)
Options
Fonction Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively.
Attributs du produit Target: VEGFR inhibitor
Receptor: VEGFR1,2,3
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Pureté 100 %
Formula C28H24FN3O5
Solubility Soluble in DMSO
Sujet Tyrosine Kinase/Adaptors
Poids moléculaire 501.50 g/mol
Numéro CAS 849217-68-1
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Stock -20 °C
Stockage commentaire For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Date de péremption 24 months