LDK378(Ceritinib)

Détails pour le produit réf. ABIN3220355
Application
Inhibition Assay (InhA), Functional Studies (Func)
Options
Fonction Ceritinib is an orally available inhibitor of the receptor tyrosine kinase activity of anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ceritinib binds to and inhibits wild-type ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to both the disruption of ALK-mediated signaling and the inhibition of cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a variety of tumor cell types.
Attributs du produit Tradename: Ceritinib
Target: TGF-beta/Smad inhibitor, IGF-1R inhibitor
Receptor: ALK,IR, IGF-1R
Status: JAN,USAN, USP
Purification All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
Pureté 100 %
Formula C28H36ClN5O3S
Solubility DMSO > 10mM
Sujet Tyrosine Kinase/Adaptors
Poids moléculaire 558.14 g/mol
Numéro CAS 1032900-25-6
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Solid
Stock -20 °C
Stockage commentaire For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.
Date de péremption 24 months