DcR1 Kit ELISA

N° du produit ABIN5510573

Détail du produit DcR1 Kit ELISA

Antigène: DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))

Épitope: AA 26-236

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human TRAILR3/ TNFRSF10C

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO, Immunogen sequence: A26-A236

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Tissue Specificity: Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))

Autre désignation: TNFRSF10C (TNFRSF10C Produits)

Synonymes: CD263 Kit ELISA, DCR1 Kit ELISA, DCR1-TNFR Kit ELISA, LIT Kit ELISA, TRAIL-R3 Kit ELISA, TRAILR3 Kit ELISA, TRID Kit ELISA, TNFRSF10C Kit ELISA, TNF receptor superfamily member 10c Kit ELISA, TNFRSF10C Kit ELISA

Sujet:

Protein Function: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

Background: TRAILR3/TNFRSF10C is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. TRAILR3 gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

Synonyms: Tumor necrosis factor receptor superfamily member 10C, Antagonist decoy receptor for TRAIL/Apo-2L, Decoy TRAIL receptor without death domain, Decoy receptor 1, DcR1, Lymphocyte inhibitor of TRAIL, TNF-related apoptosis-inducing ligand receptor 3, TRAIL receptor 3, TRAIL-R3, TRAIL receptor without an intracellular domain, CD263, TNFRSF10C, DCR1, LIT, TRAILR3, TRID, UNQ321/PRO366,

Full Gene Name: TNF receptor superfamily member 10c

Cellular Localisation: Cell membrane, Lipid-anchor, GPI-anchor.

UniProt: O14798

Pathways: Apoptose