LARGE Produits
(Like-Glycosyltransferase (LARGE))
Catégories
This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008].
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Catégories LARGE en vedette
LARGE Anticorps
High quality antibodies with extensive validation data.
LARGE Kits ELISA
Reliable ELISA kits for a wide range of species.
LARGE Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
LARGE recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IP, IHC, ICC
Validations
- (2)
N° du produit
ABIN7443668
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB
Validations
- (1)
N° du produit
ABIN6243442
Quantité
50 μL
Fiche technique
Fiche technique
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
- (1)
N° du produit
ABIN6743423
Quantité
100 μL
Fiche technique
Fiche technique
LARGE recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1135279
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1135280
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Chicken
Analytical Method
Validations
N° du produit
ABIN1135278
Quantité
96 tests
Fiche technique
Fiche technique
LARGE recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1309153
Quantité
25 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Insect Cells
Validations
N° du produit
ABIN3137603
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
N° du produit
ABIN3093482
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits LARGE
: "Overexpression of LARGE suppresses muscle regeneration via down-regulation of insulin-like growth factor 1 and aggravates muscular dystrophy in mice." dans: Human molecular genetics, Vol. 23, Issue 17, pp. 4543-58, (2014) (PubMed).: "Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain." dans: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27585-603, (2014) (PubMed).
: "Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE." dans: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11279-84, (2009) (PubMed).
Synonymes et noms alternatifs relatifs à LARGE
LARGE xylosyl- and glucuronyltransferase 1 L homeolog (large1.L), LARGE xylosyl- and glucuronyltransferase 1 (LARGE1), LARGE xylosyl- and glucuronyltransferase 1 (Large1), LARGE xylosyl- and glucuronyltransferase 1 (large1), glycosyltransferase-like protein LARGE1 (LOC100118066), like-glycosyltransferase (LARGE), like-glycosyltransferase (Large), BPFD36, DKFZp459G0120, enr, fg, froggy, Gyltl1a, gyltl1b, gyltl1b-b, Mbp-1, Mbp1, mdc1d, MDC1D, MDDGA6, MDDGB6, mKIAA0609, myd, NV15834Protein level used designations for LARGE
- glycosyltransferase-like 1B
- glycosyltransferase-like 1B-B
- glycosyltransferase-like protein LARGE2-B
- acetylglucosaminyltransferase-like 1A
- acetylglucosaminyltransferase-like protein
- glycosyltransferase-like protein LARGE1
- like-acetylglucosaminyltransferase
- myodystrophy
- glycosyltransferase-like 1A
- like-glycosyltransferase
- glycosyltransferase-like protein LARGE1-like
- eosinophil granule major basic protein 1
- prepro major basic protein 1
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