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anti-Human LCAT Anticorps:
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Human Polyclonal LCAT Primary Antibody pour ELISA, WB - ABIN152886
Furbee, Francone, Parks: In vivo contribution of LCAT to apolipoprotein B lipoprotein cholesteryl esters in LDL receptor and apolipoprotein E knockout mice. dans Journal of lipid research 2002
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Human Polyclonal LCAT Primary Antibody pour ICC, IF - ABIN438375
Lee, Badeau, Mulya, Boudyguina, Gebre, Smith, Parks: Functional LCAT deficiency in human apolipoprotein A-I transgenic, SR-BI knockout mice. dans Journal of lipid research 2007
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Cow (Bovine) Polyclonal LCAT Primary Antibody pour WB - ABIN2776941
Calabresi, Pisciotta, Costantin, Frigerio, Eberini, Alessandrini, Arca, Bon, Boscutti, Busnach, Frascà, Gesualdo, Gigante, Lupattelli, Montali, Pizzolitto, Rabbone, Rolleri, Ruotolo, Sampietro, Sessa, Vaudo, Cantafora, Veglia, Calandra, Bertolini, Frances: The molecular basis of lecithin:cholesterol acyltransferase deficiency syndromes: a comprehensive study of molecular and biochemical findings in 13 unrelated Italian families. dans Arteriosclerosis, thrombosis, and vascular biology 2005
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Single Nucleotide Polymorphism in LCAT gene is associated with dyslipidemia.
data suggests a model wherein the active site of LCAT is shielded from soluble substrates by a dynamic lid until it interacts with HDL (Montrer HSD11B1 Anticorps) to allow transesterification to proceed
Increased LCAT activity may be associated with increased formation of triglyceride rich lipoproteins, leading to a reduction in LDL particle size and atherosclerosis.
Mapping the naturally occurring mutations onto the structure provides insight into how they may affect LCAT enzymatic activity.
Report slightly reduction in LCAT that would probably reflect a delay in reverse cholesterol transport occurring in MetS (Montrer ETV3 Anticorps).
rs5923 polymorphism is not associated with low high-density lipoprotein cholesterol(HDL (Montrer HSD11B1 Anticorps)-C)levels in Iranian population
increased cholesterol esterification by LCAT is atheroprotective
The data indicate that this novel apoA-I (Montrer APOA1 Anticorps) missense is associated with markedly decreased levels of HDL (Montrer HSD11B1 Anticorps) cholesterol and very large alpha-1 HDL (Montrer HSD11B1 Anticorps), as well as decreased serum cellular cholesterol efflux and LCAT activity
A robust all-atom model for LCAT generated by homology modeling
This study investigated how the natural LCAT[T147I] and LCAT[P274S] mutations affect the pathway of biogenesis of high-density lipoproteins.
Taken together, these results suggest that apoE (Montrer APOE Anticorps)-containing discoidal HDLs (Montrer CSF1R Anticorps) do not require LCAT-dependent maturation to mediate efficient Abeta (Montrer APP Anticorps) clearance
Gene transfer of WT LCAT in LCAT(-/-) mice increased 11.8-fold the plasma cholesterol, whereas the LCAT[T147I] and LCAT[P274S] mutants caused a 5.2- and 2.9-fold increase, respectively.
DYRK1A (Montrer DYRK1A Anticorps) overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I (Montrer APOA1 Anticorps) levels.
adrenal glucocorticoid function in LCAT knockout (KO) mice
a novel function of apoA-IV (Montrer APOA4 Anticorps) in the biogenesis of discrete HDL (Montrer HSD11B1 Anticorps)-A-IV particles with the participation of ABCA1 (Montrer ABCA1 Anticorps) and LCAT
Studies suggest that absence of lecithin cholesterol acyltransferase (LCAT) may protect against insulin (Montrer INS Anticorps) resistance, diabetes and obesity.
Data show that LCAT activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2 (Montrer SPTLC2 Anticorps))+/- and sphingomyelin synthase 2 (Sms2 (Montrer SGMS2 Anticorps))-/- mice, but markedly lower in ApoE (Montrer APOE Anticorps)-/- and Ldlr (Montrer LDLR Anticorps)-/- mice.
LCAT deficiency confers gender-specific protection against diet-induced obesity and insulin (Montrer INS Anticorps) resistance at least in part through regulation in UPR, white adipose tissue adipogenesis, and brown adipocyte partitioning
Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E (Montrer APOE Anticorps) knockout background in association with a reduction in atherosclerosis
LCAT cholesterol esterification is associated with the increase of ApoE (Montrer APOE Anticorps)/ApoA-I (Montrer APOA1 Anticorps) ratio during atherosclerosis progression in rabbit.
The 1,434 bp mRNA sequence of porcine LCAT including the full coding region and encoding a protein of 472 amino acids, was obtained.
This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency.
, phospholipid-cholesterol acyltransferase
, lecithin-cholesterol acyltransferase Lcat
, lecithin-cholesterol acyltransferase
, lecithin cholesterol acyltransferase
, Lecithin-cholesterol acyltransferase