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LRP2 Produits

(Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009].

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Catégories LRP2 en vedette

LRP2 Anticorps

High quality antibodies with extensive validation data.

LRP2 Kits ELISA

Reliable ELISA kits for a wide range of species.

LRP2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

LRP2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Application FACS, IF (cc), IF (p)
Validations
  • (1)
N° du produit ABIN750991
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse
Application ELISA, FACS, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
  • (2)
  • (4)
N° du produit ABIN750988
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (3)
N° du produit ABIN7158571
Quantité 100 μg
Fiche technique Fiche technique

LRP2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6968352
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6968350
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6999575
Quantité 96 tests
Fiche technique Fiche technique

LRP2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3083291
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3130822
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7397174
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits LRP2

Kinguchi, Wakui, Azushima, Haruhara, Koguchi, Ohki, Uneda, Matsuda, Haku, Yamaji, Yamada, Kobayashi, Minegishi, Ishigami, Yamashita, Fujikawa, Tamura: "Effects of ATRAP in Renal Proximal Tubules on Angiotensin-Dependent Hypertension." dans: Journal of the American Heart Association, Vol. 8, Issue 8, pp. e012395, (2019) (PubMed).

Mohr, Voggel, Vohlen, Dinger, Dafinger, Fink, Göbel, Liebau, Dötsch, Alejandre Alcazar: "IL-6/Smad2 signaling mediates acute kidney injury and regeneration in a murine model of neonatal hyperoxia." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 5, pp. 5887-5902, (2019) (PubMed).

Fels, Scharner, Zarbock, Zavala Guevara, Lee, Barbier, Thévenod: "Cadmium Complexed with β2-Microglubulin, Albumin and Lipocalin-2 rather than Metallothionein Cause Megalin:Cubilin Dependent Toxicity of the Renal Proximal Tubule." dans: International journal of molecular sciences, Vol. 20, Issue 10, (2019) (PubMed).

Przepiorski, Sander, Tran, Hollywood, Sorrenson, Shih, Wolvetang, McMahon, Holm, Davidson: "A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells." dans: Stem cell reports, Vol. 11, Issue 2, pp. 470-484, (2018) (PubMed).

Schuh, Polesel, Platonova, Haenni, Gassama, Tokonami, Ghazi, Bugarski, Devuyst, Ziegler, Hall: "Combined Structural and Functional Imaging of the Kidney Reveals Major Axial Differences in Proximal Tubule Endocytosis." dans: Journal of the American Society of Nephrology : JASN, Vol. 29, Issue 11, pp. 2696-2712, (2018) (PubMed).

Li, Lei, Tang, Pan, Tong, Sun, Sheikh-Hamad: "Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism." dans: Cellular and molecular life sciences : CMLS, Vol. 75, Issue 21, pp. 4021-4040, (2018) (PubMed).

Viall, Chen, Stone, Chamley: "Human extravillous trophoblasts bind but do not internalize antiphospholipid antibodies." dans: Placenta, Vol. 42, pp. 9-16, (2016) (PubMed).

Erikci, Ucar, Yabanoglu-Ciftci: "Role of serotonin in the regulation of renal proximal tubular epithelial cells." dans: Renal failure, Vol. 38, Issue 7, pp. 1141-50, (2016) (PubMed).

Thelen, Abouhamed, Ciarimboli, Edemir, Bähler: "Rho GAP myosin IXa is a regulator of kidney tubule function." dans: American journal of physiology. Renal physiology, Vol. 309, Issue 6, pp. F501-13, (2015) (PubMed).

Kawano, Ito, Kanai, Nakamura, Tada, Takai, Horie, Kobayashi, Hino: "Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway." dans: Oncology reports, Vol. 34, Issue 5, pp. 2251-8, (2015) (PubMed).

Synonymes et noms alternatifs relatifs à LRP2

LDL receptor related protein 2 (LRP2), low density lipoprotein receptor-related protein 2a (lrp2a), low density lipoprotein receptor-related protein 2 (LRP2), low-density lipoprotein receptor-related protein 2 (LRP2.3), LDL receptor related protein 2 L homeolog (lrp2.L), low-density lipoprotein receptor-related protein 2 (LOC100183506), LDL receptor related protein 2 (lrp2), low density lipoprotein receptor-related protein 2 (Lrp2), LDL receptor related protein 2 (Lrp2), AI315343, AW536255, D230004K18Rik, dbs, DBS, gp330, GP330, Gp330, im:680590, lrp2, megalin, Megalin

Protein level used designations for LRP2

  • low density lipoprotein-related protein 2
  • gp330b
  • low-density lipoprotein receptor-related protein 2
  • megalin
  • low density lipoprotein receptor-related protein 2
  • low-density lipoprotein receptor-related protein 2-like
  • Heymann nephritis antigen homolog
  • LRP-2
  • calcium sensor protein
  • glycoprotein 330
  • gp330
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