MCM6 Produits
(Minichromosome Maintenance Complex Component 6 (MCM6))
Catégories
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012].
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Catégories MCM6 en vedette
MCM6 Anticorps
High quality antibodies with extensive validation data.
MCM6 Kits ELISA
Reliable ELISA kits for a wide range of species.
MCM6 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
MCM6 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF, IP
Validations
- (7)
N° du produit
ABIN3022687
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
IHC, StM
Validations
- (5)
N° du produit
ABIN6940016
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, IHC (p), PLA
Validations
- (5)
N° du produit
ABIN517783
Quantité
50 μg
Fiche technique
Fiche technique
MCM6 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6968631
Quantité
96 tests
Fiche technique
Fiche technique
MCM6 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1310559
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1310561
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3093725
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits MCM6
: "MCM6 promotes metastasis of hepatocellular carcinoma via MEK/ERK pathway and serves as a novel serum biomarker for early recurrence." dans: Journal of experimental & clinical cancer research : CR, Vol. 37, Issue 1, pp. 10, (2018) (PubMed).: "Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate." dans: Oncotarget, Vol. 5, Issue 5, pp. 1326-37, (2014) (PubMed).
: "Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells." dans: Nature, Vol. 512, Issue 7513, pp. 198-202, (2014) (PubMed).
: "The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia." dans: Journal of immunological methods, Vol. 370, Issue 1-2, pp. 1-13, (2011) (PubMed).
: "A five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 6, pp. 1490-501, (2011) (PubMed).
: "Complete in vitro reconstitution of adeno-associated virus DNA replication requires the minichromosome maintenance complex proteins." dans: Journal of virology, Vol. 82, Issue 3, pp. 1458-64, (2008) (PubMed).
: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." dans: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).
: "Stepwise regulated chromatin assembly of MCM2-7 proteins." dans: The Journal of biological chemistry, Vol. 275, Issue 12, pp. 8426-31, (2000) (PubMed).
: "Distinct phosphoisoforms of the Xenopus Mcm4 protein regulate the function of the Mcm complex." dans: Molecular and cellular biology, Vol. 20, Issue 10, pp. 3667-76, (2000) (PubMed).
: "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity." dans: Molecular and cellular biology, Vol. 19, Issue 12, pp. 8003-15, (2000) (PubMed).
Synonymes et noms alternatifs relatifs à MCM6
Minichromosome maintenance 6 (Mcm6), DNA replication licensing factor MCM6 (TP02_0113), DNA replication licensing factor MCM6 (PVX_114735), DNA replication licensing factor MCM6 (CMU_027970), minichromosome maintenance complex component 6 (MCM6), minichromosome maintenance complex component 6 (Mcm6), minichromosome maintenance complex component 6 L homeolog (mcm6.L), DNA replication licensing factor mcm-6 (mcm-6), ASP-l1, CG4039, D1Wsu22e, Dmel\\CG4039, DmeMCM6, DmMCM6, fs(1)K1214, MCG40308, MCM6, McM6, mcm6, Mcmd6, Mis5, mis5, mmcm6, P105MCMProtein level used designations for MCM6
- CG4039-PA
- Mcm6-PA
- female sterile(1)K1214
- minichromosome maintenance 6
- DNA replication licensing factor MCM6
- MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
- minichromosome maintenance deficient (mis5, S. pombe) 6
- minichromosome maintenance deficient 6 homolog
- intestinal DNA replication protein
- mini chromosome maintenance deficient 6
- minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
- maternal DNA replication licensing factor mcm6
- maternal minichromosome maintenance protein 6
- mis5p
- xMCM6
- mis5 homolog
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