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anti-Human CYP27B1 Anticorps:
anti-Rat (Rattus) CYP27B1 Anticorps:
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Human Polyclonal CYP27B1 Primary Antibody pour FACS, IHC (p) - ABIN652999
Simon, Munger, Xing Yang, Ascherio: Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis. dans Multiple sclerosis (Houndmills, Basingstoke, England) 2010
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Human Polyclonal CYP27B1 Primary Antibody pour IHC (fro), WB - ABIN541861
Bland, Walker, Hughes, Stewart, Hewison: Constitutive expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in a transformed human proximal tubule cell line: evidence for direct regulation of vitamin D metabolism by calcium. dans Endocrinology 1999
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Data show that in tissue and secreted cells from the infected mammary glands, 25-hydroxyvitamin D(3) 1alpha-hydroxylase (1alpha-OHase; CYP27B1) gene expression was significantly increased compared to expression in tissue and cells from the healthy mammary tissue.
Expression analysis showed significant CYP27B1 upregulation in epileptic male patients aged between 30 and 40.
We showed that the AA genotype of VDR polymorphism is associated with Familial Mediterranean fever (Montrer MEFV Anticorps) in males but not in females
We observed associations between VDR, GC, and CYP27B1 variants and maternal 25-hydroxyvitamin D concentration. Our results provide additional support for a possible role of genetic variation in vitamin D metabolism genes on vitamin D status during pregnancy.
colorectal cancer (CRC (Montrer CALR Anticorps)) patients had a higher frequence of insufficient vitamin D and a higher concentration of active vitamin D. These concentration were higher between patients with polymorphic genotypes variants of ApaI and BsmI, CYP24A1 (Montrer CYP24A1 Anticorps) and CYP27B1. Polymorphic genotypes cause a lower correlation between the forms of vitamin D.
in teens with positive recto-vaginal group B streptococcus colonization, placental mRNA expression of CYP27B1 is lower compared to those who tested negative for this infection
Dietary habits, lifestyle, and polymorphisms in VDR (ApaI), CYP24A1 (Montrer CYP24A1 Anticorps) (rs6013897, rs158552, rs17217119) and CYP27B1 (rs10877012) were associated with a higher risk of colorectal cancer
primary human osteoblasts in the presence of high calcium concentrations increase their CYP27B1 mRNA levels by 1.3-fold
The multiple sclerosis-associated regulatory variant rs10877013 affects expression of CYP27B1 and VDR under inflammatory or vitamin D stimuli.
The local regulation of vitamin D in sinonasal tissue during chronic rhinosinusitis may be independent of serum 25(OH)D levels. Vitamin D may be dysregulated at multiple levels, with decreased transcription of the metabolic gene CYP27B1 and increased transcription of the catabolic gene CYP24A1 (Montrer CYP24A1 Anticorps).
IL-13 (Montrer IL13 Anticorps) suppressed cyp27b1 expression in CD14 (Montrer NDUFA2 Anticorps)(+) cells. IL-13 (Montrer IL13 Anticorps) increased expression of miR (Montrer MLXIP Anticorps)-19a in CD14 (Montrer NDUFA2 Anticorps)(+) cells. IL-13 (Montrer IL13 Anticorps) suppresses cyp27b1 expression in peripheral CD14 (Montrer NDUFA2 Anticorps)(+) cells via up regulating miR (Montrer MLXIP Anticorps)-19a expression.
These results reveal that differential regulation of Cyp27b1 expression represents a mechanism whereby 1,25(OH)2D3 can fulfill separate functional roles, first in the kidney to control mineral homeostasis and second in extra-renal cells to regulate target genes linked to specific biological responses.
The data indicate that abnormal osteoclastogenesis due to the absence of CYP27B1 expression, consistent with the notion that endogenous metabolism of 25-hydroxyvitamin D optimizes osteoclastogenesis and ameliorates the resulting activity of mature osteoclasts.
The absence of 25-hydroxyvitamin D3-1alpha-hydroxylase potentiates the suppression of EAE in mice by ultraviolet light.
Cyp27b1(-/-) mice exhibited hypocalcemia, growth defects, and skeletogenesis dysfunction, similar to Vdr(-/-) mice, but do not display alopecia
Findings demonstrate that in-tumor CYP27B1 1-alpha-hydroxylase activity plays a crucial role in controlling early oncogene (Montrer RAB1A Anticorps)-mediated mammary carcinogenesis events, at least in part by modulating tumoral cell NF-kappaB (Montrer NFKB1 Anticorps) p65 (Montrer NFkBP65 Anticorps) nuclear translocation.
the effect of 25-hydroxyvitamin D-1-alpha-hydroxylase on the atherosclerosis disease both in apolipoprotein (apo) E (Montrer APOE Anticorps)-/- mice and wild-type mice, was investigated.
P450C1 alpha deficiency results in abnormal calcium handling and cardiac dysfunction in mice with defective vitamin D signaling.
Throughout the male reproductive tract specific bands of CYP27B1 are determined.
observed a 3- to 10-fold increase in CYP27B1 mRNA abundance in the lung, spleen, aorta and testis of FGF-23 (Montrer FGF23 Anticorps) null/1alpha-Luc mice
Data show that the absence of either of the two key hydroxylases, vitamin D 25-hydroxylase (CYP2R1 (Montrer CYP2R1 Anticorps)) or vitamin D 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)neither inhibits nor enhances the development of experimental autoimmune encephalomyelitis (EAE).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
cytochrome P450, family 27, subfamily B, polypeptide 1
, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
, mitochondrial 25 hydroxyvitamin D3-1alpha-hydroxylase
, 25 hydroxyvitamin D3-1-alpha hydroxylase
, 25-OHD-1 alpha-hydroxylase
, VD3 1A hydroxylase
, calcidiol 1-monooxygenase
, cytochrome P450 subfamily XXVIIB polypeptide 1
, cytochrome P450C1 alpha
, cytochrome P450VD1-alpha
, cytochrome p450 27B1
, 25-hydroxyvitamin D(3) 1-alpha-hydroxylase
, P450C1 alpha
, cytochrome P450 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase)
, cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1
, cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase)
, cytochrome P450, subfamily 27b, polypeptide 1
, 25(OH)D 1alpha-hydroxylase
, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D3 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha)
, 25-hydroxyvitamin D3 1alpha-hydroxylase
, cytochrome P450, 27b1