p21 Produits
(Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
Catégories
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010].
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Catégories p21 en vedette
p21 Anticorps
High quality antibodies with extensive validation data.
p21 Kits ELISA
Reliable ELISA kits for a wide range of species.
p21 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
p21 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (3)
- (7)
N° du produit
ABIN3022006
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (6)
N° du produit
ABIN7255634
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF, PLA
Validations
- (2)
- (5)
N° du produit
ABIN560309
Quantité
100 μg
Fiche technique
Fiche technique
p21 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966175
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Cow
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966176
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6955163
Quantité
96 tests
Fiche technique
Fiche technique
p21 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122536
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122535
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1349005
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits p21
: "Evidence that SARS-CoV-2 Induces Lung-Cell Senescence: Potential Impact on COVID-19 Lung Disease." dans: American journal of respiratory cell and molecular biology, (2021) (PubMed).: "Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A." dans: Molecular medicine reports, Vol. 22, Issue 5, pp. 3873-3885, (2021) (PubMed).
: "p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence." dans: Matrix biology : journal of the International Society for Matrix Biology, (2019) (PubMed).
: "Luteolin modulates gene expression related to steroidogenesis, apoptosis, and stress response in rat LC540 tumor Leydig cells." dans: Cell biology and toxicology, (2019) (PubMed).
: "Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells." dans: Experimental cell research, Vol. 370, Issue 2, pp. 292-302, (2018) (PubMed).
: "LncRNA GACAT3 acts as a competing endogenous RNA of HMGA1 and alleviates cucurbitacin B-induced apoptosis of gastric cancer cells." dans: Gene, (2018) (PubMed).
: "Dicer1 downregulation by multiple myeloma cells promotes the senescence and tumor-supporting capacity and decreases the differentiation potential of mesenchymal stem cells." dans: Cell death & disease, Vol. 9, Issue 5, pp. 512, (2018) (PubMed).
: "Cullin3/KCTD5 induces monoubiquitination of ΔNp63α and impairs its activity." dans: FEBS letters, Vol. 592, Issue 13, pp. 2334-2340, (2018) (PubMed).
: "Radiation-induced premature cellular senescence involved in glomerular diseases in rats." dans: Scientific reports, Vol. 8, Issue 1, pp. 16812, (2018) (PubMed).
: "DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 7, pp. E1224-E1233, (2017) (PubMed).
Synonymes et noms alternatifs relatifs à p21
cyclin D1 (CCND1), cyclin dependent kinase inhibitor 1A (CDKN1A), cyclin-dependent kinase inhibitor 1A (P21) (Cdkn1a), cyclin-dependent kinase inhibitor 1A (Cdkn1a), cyclin-dependent kinase inhibitor 1A L homeolog (cdkn1a.L), cyclin-dependent kinase inhibitor 1 (cki1), cyclin-dependent kinase inhibitor 1A (cdkn1a), cyclin dependent kinase inhibitor 1A (Cdkn1a), KRAS proto-oncogene, GTPase (KRAS), CAP20, cap20, CCND1, CDKI, CDKN1, Cdkn1, cdkn1, CDKN1A, CIP1, Cip1, cip1, KRAS2, MDA-6, mda-6, mda6, p16Xic2, P21, p21, p21CIP1, p21Cip1, p21cip1, p21ras, p21WAF, SDI1, sdi1, si:ch1073-48m5.2, UV96, WAF1, Waf1, waf1Protein level used designations for p21
- cyclin D1
- cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- CDK-interacting protein 1
- CDK-interaction protein 1
- DNA synthesis inhibitor
- cyclin-dependent kinase inhibitor 1
- melanoma differentiation associated protein 6
- wild-type p53-activated fragment 1
- melanoma differentiation-associated protein
- p21
- cyclin-dependent kinase inhibitor 1A (P21)
- cyclin dependent kinase inhibitor p16Xic2
- cip1
- p21
- waf1
- cyclin-dependent kinase inhibitor 1A
- p21/WAF1
- GTPase KRas
- Kirsten rat sarcoma viral (Kras-2) oncogene homolog
- v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
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