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anti-Rat (Rattus) CDX2 Anticorps:
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Human Polyclonal CDX2 Primary Antibody pour IHC (p), IP - ABIN151575
Verzi, Hatzis, Sulahian, Philips, Schuijers, Shin, Freed, Lynch, Dang, Brown, Clevers, Liu, Shivdasani: TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. dans Proceedings of the National Academy of Sciences of the United States of America 2010
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Human Polyclonal CDX2 Primary Antibody pour IHC (p), ELISA - ABIN545638
Bai, Miyake, Iwai, Yuasa: CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. dans Oncogene 2003
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Human Monoclonal CDX2 Primary Antibody pour ELISA, WB - ABIN1724918
Lee, Vogt, Hsiao, Osunkoya: CDX-2 expression in malignant germ cell tumors of the testes, intratubular germ cell neoplasia, and normal seminiferous tubules. dans Tumour biology 2012
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Human Monoclonal CDX2 Primary Antibody pour FACS, ELISA - ABIN1724921
Liu, Zhang, Zhan, Brock, Herman, Guo: CDX2 serves as a Wnt signaling inhibitor and is frequently methylated in lung cancer. dans Cancer biology & therapy 2012
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Human Polyclonal CDX2 Primary Antibody pour ELISA, WB - ABIN251330
Qualtrough, Hinoi, Fearon, Paraskeva: Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system. dans Gut 2002
Human Monoclonal CDX2 Primary Antibody pour IHC (p), IHC - ABIN152122
Flisikowska, Merkl, Landmann, Eser, Rezaei, Cui, Kurome, Zakhartchenko, Kessler, Wieland, Rottmann, Schmid, Schneider, Kind, Wolf, Saur, Schnieke: A porcine model of familial adenomatous polyposis. dans Gastroenterology 2012
Dog (Canine) Polyclonal CDX2 Primary Antibody pour ELISA, WB - ABIN547648
Wells, Melton: Vertebrate endoderm development. dans Annual review of cell and developmental biology 2000
Cow (Bovine) Polyclonal CDX2 Primary Antibody pour WB - ABIN2777319
Saad, Cho, Silverman, Liu: Usefulness of Cdx2 in separating mucinous bronchioloalveolar adenocarcinoma of the lung from metastatic mucinous colorectal adenocarcinoma. dans American journal of clinical pathology 2004
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Human Monoclonal CDX2 Primary Antibody pour ELISA, WB - ABIN560320
Zulueta, Caretti, Signorelli, Dallolio, Trinchera: Transcriptional control of the B3GALT5 gene by a retroviral promoter and methylation of distant regulatory elements. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014
These results provide evidence that CDX2 plays an essential role in functional trophectoderm formation during primate embryonic development.
Study aimed to explain Cdx-2 variant association with immune-related conditions. Authors hypothesised that the effect of Cdx-2 polymorphism on VDR expression in monocytes/macrophages, devoid of the CDX-2 TF, is indirect and dependent on circulating 25(OH)D3 and VDR methylation.
Data show that data demonstrate that tumor protein translationally-controlled 1 (TCTP) overexpression has a promotion effect on caudal type homeo box transcription factor 2 protein (CDX2) and villin1 protein (VIL1) expression.
Transfection of LS174T cells showed that the VTI1A promoter is highly active compared to the TCF7L2 promoter, and that CDX2 activates transcription of VTI1A.
The damaging p.Cys132* and p.Arg237His de novo CDX2 variants were identified in two patients. These variants altered the expression of CYP26A1, a direct CDX2 target encoding the major retinoic acid (RA)-degrading enzyme. Other RA genes, including the RA-receptor alpha, were also mutated.
Sbno1 knockout embryos die at the preimplantation stage without forming a blastocoel, and Cdx2 is not turned on even though both Yap and Tead4 reside normally in nuclei.
LEF-1 and CDX2 performed at least as well as beta-catenin, if not better, as a diagnostic marker for pilomatrical carcinomas
Study indicates that CDX2 expression can predict lack of response to NAT.
CDX2 is not an independent prognostic biomarker in colorectal cancer
This study characterized a new and original variant of the CDX2 homeobox gene.
CDX2 is highly expressed along the atrophic gastritis-metaplasia-dysplasia-cancer sequential. Though CDX2 expression is quite dominant in IM ( intestinal metaplasia), but its expression is not associated with H. pylori (Helicobacter pylori) infection.
of CDX2 using a hypoxia-inducible hTERT promoter-driven vector suppressed malignant progression of colon cancer cells in vitro and in vivo.These results suggest that pLVX-5HRE-hTERTp-CDX2-3FLAG gene therapy may be a promising novel approach to treat colon cancer
The results of the present study show that a lack of CDX2 expression in metastatic colorectal cancer is an adverse prognostic feature and a potential negative predictor of the response to chemotherapy.
We may conclude that hTERT promotes GIM by up-regulating CDX2 via NF-kappaB signaling pathway.
Our work suggests that combination of the consensual CMS classification and lack of CDX2 expression could be a useful marker to identify CMS4/CDX2-negative patients with a very poor prognosis
AMPK enhances intestinal barrier function and epithelial differentiation via promoting CDX2 expression, which is partially mediated by altered histone modifications in the Cdx2 promoter.
Findings suggest that H. pylori infectionis a driving force of gastric cardia carcinogenesis by upregulating caudal-related homeobox transcription factor 2 (CDX2) and inducing inflammation.
Data show that a two-marker panel of p40 (DeltaNp63) and CDX2 is highly sensitive and specific.
our findings demonstrated that MDR1 expression is regulated by CDX2 and is related to drug resistance in ovarian mucinous adenocarcinoma.
The data presented provide a novel insight into how CDX2 is implicated in the transcriptional regulation of LAMC2 in intestinal epithelial cells, a function that is impaired during mucosal inflammation where a high level of TNF-alpha is present.
Cytapheresis might induce CDX2 expression without affecting the cell proliferation, thus resulting in mucosal healing with goblet cell restoration.
Data show that SLC7A7 is a CDX2 target gene, and that CDX2 binds directly to the SLC7A7 promoter.
these results provide further insight into the functional diversity of CDX2 in early mammalian embryos.
showed novel molecular regulation of CDX2 on Oct4, and provided important clues for clarifying the mechanism of interaction between CDX2 and Oct4 in embryo of mammals other than mouse
Results reveal an early regulatory switch in Cdx2 expression and show that different inputs are needed to drive Cdx2 expression in the blastocyst trophectoderm and in trophoblast stem cells.
CDX2(Null)/BRAF(V600E) expression in adult mouse intestinal epithelium led to serrated morphology tumors (including carcinomas) and BRAF(V600E) potently interacted with CDX2 silencing to alter gene expression. Like human serrated lesions, CDX2(Null)/BRAF(V600E)-mutant epithelium expressed gastric markers.
including Wnt and Fgf pathway components active in the axial progenitor niche. Our data demonstrate that integration of the Cdx/Hox and T Brachyury transcriptional networks controls differential axial growth during vertebrate trunk elongation
A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 and HNF4alpha were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 and HNF4alpha in human biopsy samples.
Cdx members interact with the SWI-SNF complex and make direct contact with Brg1, a catalytic member of SWI-SNF. Both Cdx2 and Brg1 co-occupy a number of Cdx target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 and Brg1 occupancy occurs coincident with chromatin remodeling at some of these loci.
The authors identify a Cdx2-responsive segment of HoxA, immediately 5' to the recently defined regulatory domain orchestrating initial transcription of the first Hox gene.
Cdx1-Cdx2 double null mutants exhibited loss of primitive erythroblasts, aberrant vascular remodelling of the yolk sac and a block in hematopoietic differentiation from yolk sac-derived cells in culture.
this study shows that Aloe vera gel suppresses colitis-related colon carcinogenesis via increased expression of CDX-2, a tumor suppressor in colorectal cancer
Results point out the complex interplay between the DSB DNA repair activity and the homeoproteins HoxB7 and Cdx2 in colon cancer cells.
CDX2 is required for proliferation and differentiation of intestinal stem cells. Direct CDX2 targets in ISCs may be activated or repressed.
cells in preimplantation embryos that localized in an initial outer position initiated the expression of Cdx2. cells that changed their position from an outer to an inner position downregulated Cdx2 expression and contributed to the inner cell mass.
findings illuminated a role for NOD1 signaling in attenuating H. pylori-induced Cdx2 expression in gastric epithelial cells
Overexpression of CDX2 inhibits the growth of the gastric cancer cells in vivo and in vitro.
Intestinal stem cells transform into gastric stem cells on loss of transcription factor Cdx2.
GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2
pSMAD/CDX2 interaction is essential for the switch toward an intestinal phenotype in Barrett's esophagus.
Cdx2 is important for the correct specification of trophoectoderm from the morula stage.
These findings underscore previously unrecognized roles for Cdx members in intestinal tumorigenesis
Intestinal nuclear bile acid farnesoid X receptor is regulated transcriptionally by CDX2.
results thus indicate that CDX2 is not required for TE formation during bovine development; nevertheless, it is necessary for maintaining TE integrity.
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis.
caudal type homeobox 2
, caudal type homeobox transcription factor 2
, caudal type homeo box transcription factor 2
, homeobox protein CDX-2
, caudal-type homeobox protein 2
, caudal type homeo box 2
, caudal-type homeobox transcription factor 2