Myb-Like, SWIRM and MPN Domains 1 (MYSM1) (C-Term) Peptide
MYSM1
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits MYSM1
- MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))
- Protein Region
- C-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- CLQKLLECMR KTLSKVTNCF MAEEFLTEIE NLFLSNYKSN QENGVTEENC
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-MYSM1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))
- Synonymes
- 2A-DUB Peptide, 2ADUB Peptide, RP4-592A1.1 Peptide, C130067A03Rik Peptide, C530050H10Rik Peptide, RGD1311787 Peptide, 2adub Peptide, Myb like, SWIRM and MPN domains 1 Peptide, myb-like, SWIRM and MPN domains 1 Peptide, Myb like, SWIRM and MPN domains 1 L homeolog Peptide, MYSM1 Peptide, Mysm1 Peptide, mysm1.L Peptide
- Sujet
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MYSM1 is a metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. It preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. MYSM1 acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
Alias Symbols: 2A-DUB, 2ADUB, DKFZp779J1554, DKFZp779J1721, KIAA1915, RP4-592A1.1
Protein Size: 828 - Poids moléculaire
- 91 kDa
- ID gène
- 114803
- NCBI Accession
- NM_001085487, NP_001078956
- UniProt
- Q5VVJ2
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