Non-SMC Element 4 Homolog A (NSMCE4A) (C-Term) Peptide
NSMCE4A
Reactivité: Humain
Hôte: Synthetic
BP, WB, ICC
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- Antigène Tous les produits NSMCE4A
- NSMCE4A (Non-SMC Element 4 Homolog A (NSMCE4A))
- Protein Region
- C-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunocytochemistry (ICC)
- Séquence
- PVIQEERAMP AQLRRMEESH QEATEKEVER ILGLLQTYFR EDPDTPMSFF
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-NSMCE4A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeat freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- NSMCE4A (Non-SMC Element 4 Homolog A (NSMCE4A))
- Synonymes
- 2410003A14Rik Peptide, RGD1309025 Peptide, C10orf86 Peptide, NS4EA Peptide, NSE4A Peptide, NSE4 homolog A, SMC5-SMC6 complex component Peptide, Nsmce4a Peptide, NSMCE4A Peptide
- Sujet
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NSMCE4A is a component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). It is involved in positive regulation of response to DNA damage stimulus.
Alias Symbols: C10orf86, NS4EA, NSE4A
Protein Size: 385 - Poids moléculaire
- 44 kDa
- ID gène
- 54780
- NCBI Accession
- NM_017615, NP_060085
- UniProt
- Q9NXX6
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