Protein Kinase N2 (PKN2) (C-Term) Peptide
PKN2
Reactivité: Humain, Souris
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits PKN2
- PKN2 (Protein Kinase N2 (PKN2))
- Protein Region
- C-Term
- Origine
- Humain, Souris
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- LRRNPERRLG AGEKDAEDVK KHPFFRLTDW SALMDKKVKP PFVPTIRGRE
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-Pkn2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeat freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- PKN2 (Protein Kinase N2 (PKN2))
- Synonymes
- PAK2 Peptide, PRK2 Peptide, PRKCL2 Peptide, PRO2042 Peptide, Pak-2 Peptide, 6030436C20Rik Peptide, AI507382 Peptide, Prkcl2 Peptide, Stk7 Peptide, pak2 Peptide, prk2 Peptide, pak-2 Peptide, pro2042 Peptide, PKN2 Peptide, si:ch211-83f14.1 Peptide, wu:fa97c07 Peptide, protein kinase N2 Peptide, protein kinase N2 L homeolog Peptide, PKN2 Peptide, Pkn2 Peptide, pkn2.L Peptide, pkn2 Peptide
- Sujet
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Pkn2 is a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. It plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Pkn2 phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin, phosphorylates HDAC5, therefore lead to impair HDAC5 import. It is a direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells and is required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. It stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation, regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion, inhibits Akt pro-survival-induced kinase activity. It mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF).
Alias Symbols: 6030436C20Rik, AI507382, PRK2, Prkcl2, Stk7
Protein Size: 983 - Poids moléculaire
- 111 kDa
- ID gène
- 109333
- NCBI Accession
- NM_178654, NP_848769
- UniProt
- Q8BWW9
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