(3 références)-
- Antigène Tous les produits PAR1 (F2R)
- PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))
- Application
- Agonist (Agon)
- Purification
- Serum
- Pureté
- 95 %
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- Restrictions
- For Research Use only
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- Stock
- -20 °C
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: "Thrombin induces release of proinflammatory chemokines interleukin-8 and interferon-?-induced protein-10 from cultured human fetal astrocytes." dans: Neuroreport, Vol. 24, Issue 1, pp. 36-40, (2012) (PubMed).
: "Thrombin-induced regulation of CD95(Fas) expression in the N9 microglial cell line: evidence for involvement of proteinase-activated receptor(1) and extracellular signal-regulated kinase 1/2." dans: Neurochemical research, Vol. 34, Issue 3, pp. 445-52, (2009) (PubMed).
: "Thrombin regulates CD40 expression in microglial cells." dans: Neuroreport, Vol. 19, Issue 7, pp. 757-60, (2008) (PubMed).
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: "Thrombin induces release of proinflammatory chemokines interleukin-8 and interferon-?-induced protein-10 from cultured human fetal astrocytes." dans: Neuroreport, Vol. 24, Issue 1, pp. 36-40, (2012) (PubMed).
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- Antigène
- PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))
- Synonymes
- CF2R Peptide, HTR Peptide, PAR-1 Peptide, PAR1 Peptide, TR Peptide, Par1 Peptide, TRGPC Peptide, AI482343 Peptide, Cf2r Peptide, ThrR Peptide, Par-1 Peptide, f2r-a Peptide, par1 Peptide, coagulation factor II thrombin receptor Peptide, coagulation factor II (thrombin) receptor Peptide, coagulation factor 2 (thrombin) receptor L homeolog Peptide, F2R Peptide, F2r Peptide, f2r.L Peptide
- Sujet
- This hexapeptide corresponding to residues 42-47 of the thrombin receptor has been shown to be a thrombin receptor activator. It caused half-maximal platelet aggregation at approx. 0.8 uM and was 5 times more potent than the parent peptide H-8105. In addition, SFLLRN is effective in causing tyrosine phosphorylation, inhibition of cAMP formation, and an increase in cytosolic Ca2+.
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