V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (C-Term) Peptide
ERBB4
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits ERBB4
- ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))
- Protein Region
- C-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- NTFANTLGKA EYLKNNILSM PEKAKKAFDN PDYWNHSLPP RSTLQHPDYL
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-ERBB4 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))
- Synonymes
- erbb4 Peptide, si:ch211-227n20.1 Peptide, Her4 Peptide, c-erbB-4 Peptide, HER4 Peptide, p180erbB4 Peptide, erb-b2 receptor tyrosine kinase 4 Peptide, erb-b2 receptor tyrosine kinase 4a Peptide, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) Peptide, erb-b2 receptor tyrosine kinase 4 L homeolog Peptide, receptor tyrosine-protein kinase ErbB-4 Peptide, ERBB4 Peptide, erbb4a Peptide, erbb4 Peptide, erbb4.L Peptide, Tsp_13582 Peptide, Erbb4 Peptide
- Sujet
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This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized.
Alias Symbols: HER4, ALS19, p180erbB4
Protein Size: 479 - ID gène
- 2066
- NCBI Accession
- NP_001036064
- UniProt
- Q53T57
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