Janus Kinase 1 (JAK1) (N-Term) Peptide
JAK1
Reactivité: Humain
Hôte: Synthetic
WB
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- Antigène Tous les produits JAK1
- JAK1 (Janus Kinase 1 (JAK1))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Western Blotting (WB)
- Séquence
- RMRFYFTNWH GTNDNEQSVW RHSPKKQKNG YEKKKIPDAT PLLDASSLEY
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- JAK1 (Janus Kinase 1 (JAK1))
- Synonymes
- JAK1A Peptide, JAK1B Peptide, JTK3 Peptide, AA960307 Peptide, C130039L05Rik Peptide, wu:fb93e10 Peptide, jak1 Peptide, Janus kinase 1 Peptide, tyrosine-protein kinase JAK1 Peptide, JAK1 Peptide, Jak1 Peptide, jak1 Peptide, LOC100286690 Peptide
- Sujet
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Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
Alias Symbols: JTK3, JAK1A, JAK1B
Protein Size: 1154 - ID gène
- 3716
- NCBI Accession
- NM_002227, NP_002218
- UniProt
- P23458
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