A synthetic peptide for use as a blocking control in assays to test for specificity of PILRA antibody, Alternative Names: PILRA control peptide, PILRA antibody Blocking Peptide, Anti-PILRA Blocking Peptide, Paired Immunoglobin-Like Type 2 Receptor Alpha Blocking Peptide, FDF03 Blocking Peptide
Optimal conditions should be determined by the investigator
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
Buffer
PBS
Conseil sur la manipulation
Avoid repeated freeze/thaw cycles.
Stock
-20 °C
Stockage commentaire
Store at -20 °C long term.
Antigène
PILRA
(Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA))
Synonymes
PILRA Peptide, FDF03 Peptide, AV021745 Peptide, RGD1562847 Peptide, paired immunoglobin like type 2 receptor alpha Peptide, paired immunoglobulin-like type 2 receptor alpha Peptide, paired immunoglobin-like type 2 receptor alpha Peptide, PILRA Peptide, LOC489841 Peptide, Pilra Peptide
Sujet
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.