Calcium Modulating Ligand (CAMLG) (N-Term) Peptide
CAMLG
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits CAMLG
- CAMLG (Calcium Modulating Ligand (CAMLG))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-CAMLG antibody (Catalog #: ARP48191_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- CAMLG (Calcium Modulating Ligand (CAMLG))
- Synonymes
- MGC53900 Peptide, CAML Peptide, AI385748 Peptide, Camlg Peptide, Caml Peptide, calcium modulating ligand L homeolog Peptide, calcium modulating ligand Peptide, camlg.L Peptide, CAMLG Peptide, camlg Peptide, Caml Peptide, Camlg Peptide
- Sujet
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The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. CAMLG functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
Alias Symbols: CAML, MGC163197
Protein Interaction Partner: IER3,EGFR,PKHD1,TNFRSF13B,EGFR,PPIB,TNFRSF13B
Protein Size: 296 - Poids moléculaire
- 33 kDa
- ID gène
- 819
- NCBI Accession
- NM_001745, NP_001736
- UniProt
- P49069
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