Calpain 10 (CAPN10) (N-Term) Peptide
CAPN10
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits CAPN10
- CAPN10 (Calpain 10 (CAPN10))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-CAPN10 antibody (Catalog #: ARP52404_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- CAPN10 (Calpain 10 (CAPN10))
- Synonymes
- CAPN10 Peptide, CANP10 Peptide, NIDDM1 Peptide, AW049679 Peptide, Capn8 Peptide, mKIAA1845 Peptide, calpain 10 Peptide, calpain 10 L homeolog Peptide, CAPN10 Peptide, capn10.L Peptide, capn10 Peptide, Capn10 Peptide
- Sujet
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CAPN10 is the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation, domain II, the protease domain, domain III, a linker domain of unknown function, and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: CANP10, NIDDM1
Protein Size: 517 - Poids moléculaire
- 58 kDa
- ID gène
- 11132
- NCBI Accession
- NM_023085, NP_075573
- UniProt
- Q9HC96
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