CD40 (CD40) Peptide
CD40
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits CD40
- CD40
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-CD40 antibody (Catalog #: ARP41929_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- CD40
- Synonymes
- Bp50 Peptide, CDW40 Peptide, TNFRSF5 Peptide, p50 Peptide, AI326936 Peptide, GP39 Peptide, HIGM1 Peptide, IGM Peptide, IMD3 Peptide, T-BAM Peptide, TRAP Peptide, Tnfrsf5 Peptide, TNFSF5 Peptide, CD40 molecule Peptide, CD40 antigen Peptide, CD40 Peptide, Cd40 Peptide
- Sujet
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CD40 is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Alias Symbols: Bp50, CDW40, MGC9013, TNFRSF5, p50
Protein Interaction Partner: TRAF2,TRAF3,TRAF3,BIRC2,BIRC3,CAV1,CBL,CD40LG,HSPA4,HSPA8,IL4R,JAK3,MAP3K8,MS4A1,NSMAF,PIK3R1,RIPK2,TDP2,TRAF1,TRAF2,TRAF3,TRAF3IP2,TRAF5,TRAF6,XRCC5,XRCC6,CALR,DDX3X,ERP44,FBL,MS4A1,NCOA6,POLR2H,RFC5,RIPK2,RNF219,SGK1,SLC30A7,SLC39A7,SUMO1,TDP2,TRAF2,TRAF3,TRAF3IP2,TRAF5,TRAF6,TXN,UGGT1,USP15,XRCC5,XRCC6
Protein Size: 277 - Poids moléculaire
- 30 kDa
- ID gène
- 958
- NCBI Accession
- NM_001250, NP_001241
- UniProt
- P25942
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