This is a synthetic peptide designed for use in combination with anti-CDC42 antibody (Catalog #: AVARP01017_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
Alias Symbols: CDC42Hs, G25K
Protein Interaction Partner: WAS,CDC42EP2,CDC42EP3,ITSN1,MCF2L,WAS,ACTR3,ANXA2,ARHGAP1,ARHGAP31,ARHGDIA,ARHGDIB,ARHGDIG,ARHGEF6,ARHGEF7,BAIAP2,BNIP2,C14orf1,C1orf103,CASP3,CASP7,CDC42BPG,CDC42EP1,CDC42EP2,CDC42EP3,CDC42EP5,CDC42SE1,CSPG4,DEF6,DOCK7,DOCK8,DOCK9,EEF1G,EIF2AK2,ERRFI1,FGD1,FLNA,FNBP1,GDI1,GEFT,IQGAP1,IQGAP2,ITSN1,KAT5,KTN1,LCK,MAP3K10,MAP3K11,MAP3K4,MARK4,MCF2L,METAP2,MYO9A,NCF2,OCRL,OPHN1,PAK1,PAK2,PAK4,PAK6,PAK7,PARD3,PARD6A,PARD6B,PARD6G,PDE6D,PGGT1B,PIK3R1,PLD1,PLEKHG2,PRKCA,PRKCG,PRKCI,PRKCZ,RAC2,RHOJ,RPS6KB1,SRGAP1,STAU1,TBC1D3F,TNK2,TP53,TRIP10,UBR1,UNC119,VAV1,WAS,WASF1,WASF2,ARHGAP1,ARHGAP1,ARHGAP10,ARHGAP17,ARHGAP26,ARHGAP27,ARHGAP29,ARHGAP32,ARHGAP8,ARHGDIA,ARHGDIG,ARHGEF6,ARHGEF7,BAIAP2,BCR,BNIP2,BNIP2,BNIP2,BNIP2,BNIPL,C14orf1,C1orf103,CDC42,CDC42BPG,CDC42EP1,CDC42EP2,CDC42EP3,CDC42EP5,CDC42SE1,CDC42SE2,CLIP1,CNTNAP1,CSPG4,DEF6,DEF6,DOCK8,DOCK9,Diap3,EEF1G,ERRFI1,FGD1,FNBP1L,GDI1,GEFT,GOPC,IQGAP1,IQGAP2,ITSN1,KAT5,Kin,MAP3K10,MAP3K11,MAP3K4,MCF2,MCF2L,NCF2,Net1,OPHN1,PAK1,PAK1,PAK1,PAK2,PAK4,PAK6,PAK7,PARD6A,PARD6B,PARD6G,PDE6D,PLD1,PLEKHG2,RAC1,RICH2,Rock1,TBC1D3F,TNK2,TP53,TRIP10,UBR1,UNC119,VAV1,WAS,WAS,WASL,tax