Cyclin-Dependent Kinase 8 (CDK8) Peptide
CDK8
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits CDK8
- CDK8 (Cyclin-Dependent Kinase 8 (CDK8))
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-CDK8 antibody (Catalog #: AVARP03050_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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-
- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Antigène
- CDK8 (Cyclin-Dependent Kinase 8 (CDK8))
- Synonymes
- K35 Peptide, wu:fk95h11 Peptide, cyclin dependent kinase 8 Peptide, cyclin-dependent kinase 8 Peptide, cyclin-dependent kinase 8 S homeolog Peptide, Cyclin-dependent kinase 8 Peptide, cyclin dependent kinase 19 Peptide, CDK8 Peptide, Cdk8 Peptide, cdk8 Peptide, cdk8.S Peptide, cdk-8 Peptide, CDK19 Peptide
- Sujet
-
The protein encoded by CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
Alias Symbols: K35
Protein Interaction Partner: MAML1,CCNC,CCNH,CDKN2B,MAML1,MED12,MED21,MED25,MED26,MED8,MED9,POLR2A,BRCA1,CCNC,CEBPB,CREBBP,ESR1,ESR2,KAT2B,MED1,MED10,MED12,MED13,MED14,MED16,MED17,MED19,MED20,MED21,MED23,MED24,MED25,MED26,MED28,MED29,MED31,MED6,MED7,MED9,POLR2A,SMARCA2,SMARCB1,SMARCC1,SMARCC2,TCEA1,THRA,THRAP3
Protein Size: 464 - Poids moléculaire
- 53 kDa
- ID gène
- 1024
- NCBI Accession
- NM_001260, NP_001251
- UniProt
- P49336
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