This is a synthetic peptide designed for use in combination with anti-HLA-DPB1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification
Purified
Indications d'application
Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Concentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Conseil sur la manipulation
Avoid repeated freeze-thaw cycles.
Stock
-20 °C
Stockage commentaire
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Antigène
HLA-DPB1
(Major Histocompatibility Complex, Class II, DP beta 1 (HLA-DPB1))
Synonymes
PATR-DPB1 Peptide, B-LB Peptide, B-LB2 Peptide, B-LB21 Peptide, BLB1 Peptide, GSP-BLB1 Peptide, DPB1 Peptide, HLA-DP Peptide, HLA-DP1B Peptide, HLA-DPB Peptide, major histocompatibility complex, class II, DP beta 1 Peptide, Major histocompatibility complex class II beta chain BLB1 Peptide, PATR-DPB1 Peptide, BLB1 Peptide, HLA-DPB1 Peptide
Sujet
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
Alias Symbols: DPB1, HLA-DP1B
Protein Interaction Partner: CD74,HLA-DPA1,ROBO2,RTN4